贵州医科大学学报

2017, v.42;No.201(06) 699-702

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重组组织型纤溶酶原激活剂静脉溶栓治疗急性脑梗死的疗效
The Effect of Intravenous Thrombolysis Therapy with Recombinant Tissue-type Plasminogen Activator on the Patients of Acute Cerebral Infarction

吴瑞;李海军;刘胜武;曹钰琨;
WU Rui;LI Haijun;LIU Shengwu;CAO Yukun;Department of heart and cerebral vessels,Yanan University Affiliated Hospital;Department of cardiac surgery,General Hospital of the PLA Air Force;

摘要(Abstract):

目的:探讨重组组织型纤溶酶原激活剂(rt-PA)静脉溶栓治疗对急性脑梗死的疗效。方法:将28例急性脑梗死患者随机分为对照组和观察组,对照组患者采用常规疗法治疗,观察组患者采取rt-PA联合常规疗法进行治疗;比较两组患者治疗前后NIHSS评分、Baethel指数,观察两组患者闭塞血管再通率和并发症发生率。结果:治疗后两组急性脑梗死患者NIHSS评分降低(P<0.05),两组比较差异无统计学意义(P>0.05);治疗后两组急性脑梗死患者Baethel指数均升高(P<0.05),且观察组患者高于对照组(P<0.05),说明观察组患者日常生活能力强于对照组;观察组并发症发生率低于对照组(P<0.05),两组患者闭塞血管再通率比较差异无统计学意义。结论:rt-PA静脉溶栓联合常规疗法可改善急性脑梗死患者日常生活能力,降低并发症发生率。
Objective: To explore the intravenous thrombolysis therapy with recombinant tissue-type plasminogen activator on the patients of acute cerebral infarction. Methods: 28 acute cerebral infarction patients were divided into two groups. The control group was given by conventional therapy,while observation group was given by intravenous thrombolysis therapy with recombinant tissue-type plasminogen activator combined with conventional therapy. NIHSS scores,Baethel index,NSE level,vascular repatency rate and complication rate of patients were compared in the two groups. Results: NIHSS scores of observation group and control group had no statistically significant difference( P > 0. 05).Baethel index in the observation group was significantly higher than in the control group( P < 0. 05).Vascular repatency rate of observation group and control group had no statistically significant difference( P > 0. 05). Complication rate in observation group was significantly lower than in control group( P <0. 05). Conclusion: Intravenous thrombolysis therapy of recombinant tissue-type plasminogen activator with conventional therapy can effectively improve Baethel index and NSE level,and reduce vascular repatency rate. The treatment of acute cerebral infarction can improve the curative effect,and reduce the adverse reaction.

关键词(KeyWords): 纤溶酶原激活剂;脑梗塞;静脉溶栓;NIHSS评分;Baethel指数
plasminogen activator;cerebral infarction;intravenous thrombolysis;NIHSS score;Baethel index

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基金项目(Foundation): 国家自然科学基金(81400908)

作者(Author): 吴瑞;李海军;刘胜武;曹钰琨;
WU Rui;LI Haijun;LIU Shengwu;CAO Yukun;Department of heart and cerebral vessels,Yanan University Affiliated Hospital;Department of cardiac surgery,General Hospital of the PLA Air Force;

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DOI: 10.19367/j.cnki.1000-2707.2017.06.017

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