贵州医科大学学报

2018, v.43;No.216(09) 1033-1037

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甲状腺乳头状微小癌中微淋巴管密度和微血管密度的检测及意义
Detection and Significance of MLD and MVD in Human Papillary Thyroid Micro-carcinoma

于德浩;胡斌;徐晋洋;李珀;何常;
YU Dehao;HU Bin;XV Jinyang;LI Po;HE Chang;Department of Pathology,Guizhou Medical University;

摘要(Abstract):

目的:探讨甲状腺乳头状微小癌中微淋巴管密度(MLD)和微血管密度(MVD)的检测及意义。方法:收集60例甲状腺乳头状微小癌标本及20例结节性甲状腺肿组织标本,采用免疫组织化学Envision两步法检测两种标本中D2-40和CD31表达情况,分别定量计数D2-40阳性表达的MLD和CD31阳性表达的MVD,分析它们与甲状腺乳头状微小癌转移的关系,并分析甲状腺乳头状微小癌中MLD与MVD的相关性。结果:甲状腺乳头状微小癌中MLD与MVD值高于结节性甲状腺肿,差异有统计学意义(P <0. 05);有淋巴结转移的甲状腺乳头状微小癌标本MLD与MVD值明显高于无转移淋巴结标本,差异有统计学意义(P <0. 05);在甲状腺乳头状微小癌中,MLD与MVD呈正相关关系(r=0. 742,P <0. 05)。结论:检测D2-40和CD31标记的MLD和MVD,对预测肿瘤淋巴结转移有潜在应用价值。
Objective: To investigate the detection and significance of MLD and MVD in papillary thyroid micro-carcinoma. Methods: 60 specimens of papillary thyroid micro-carcinoma and 20 specimens of nodular goiter tissues were collected. The expression of D2-40 and CD31 in the two kinds of specimens was detected by immunohistochemistry. The micro-lymphatic vessel density( MLD) and micro-vascular density( MVD),marked by D2-40 and CD31,in papillary thyroid micro-carcinoma and nodular goiter tissues were quantitatively counted. Also their correlation with lymph node metastasis in papillary thyroid micro-carcinoma were analyzed. Results: The values of MLD and MVD in papillary thyroid micro-carcinoma were higher than those in nodular goiter tissues,and the difference was statistically significant( P < 0. 05). The values of MLD and MVD in thyroid papillary microcarcinoma with lymph node metastasis were significantly higher than those without lymph node metastasis,and the difference was statistically significant( P < 0. 05). There was a positive correlation between MLD and MVD in papillary thyroid carcinoma( r = 0. 742,P < 0. 05). Conclusion: The detection of MLD and MVD marked by D2-40 and CD31 has potential application in predicting lymph node metastasis.

关键词(KeyWords): 微淋巴管密度;微血管密度;甲状腺肿瘤;甲状腺乳头状微小癌;免疫组织化学
micro-lymphatic vessel density;micro-vascular density;thyroid neoplasm;papillary thyroid micro-carcinoma;immunohistochemistry

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作者(Author): 于德浩;胡斌;徐晋洋;李珀;何常;
YU Dehao;HU Bin;XV Jinyang;LI Po;HE Chang;Department of Pathology,Guizhou Medical University;

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