贵州医科大学学报

1988, (02) 190-196

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急性非淋巴细胞白血病诱导缓解分析——60例报告
AN ANALYSIS OF REMISSION INDUCTION IN ACUTE NONLYMPHOCYTIC LEUKEMIA:REPORT OF 60 CASES

李卓江;景本年;晏家益;李继勋;张继恺;周力;
Li Zhuojiang,Department of Internal Medicine

摘要(Abstract):

本文报告了 COAP、HOAP 及联合化疗、小剂量阿糖胞苷(LD-Ara-C)治疗急性非淋巴细胞白血病(急非淋)60例,结果31例获得完全缓解,总完全缓解率为51.7%;COAP 组、HOAP 组及联合化疗-LD-Ara-C 组完全缓解率分别为16.7%(2/12)、53.1%(17/32)及75%(12/16);HOAP 组及联合化疗-LD-Ara-C 组完全缓解率分别显著及非常显著高于 COAP 组(P 分别<0.05及<0.01)。
This paper analyzed the therapeutic effect of COAP regimen(Cytoxan, Vincristine,Cytoxine Arabinoside and Prednisone),HOAP regimen(Homo- harringtonine,Vincristine,Cytoxine Arabinoside and Prednisone)and the combined regimen of HOAP and Low Dose Arabinoside(LD-Ara-C)as two stage method(treatment with HOAP decrease the massive leukemic cell first, and then the LD-Ara-C was follow-up)in the treatment of 60 cases aged 13-66 yrs with acute nonlymphocytic leukemia(ANLL)in our hospital in the period from Sep.1977 to Dec.1986.31 out of 60 cases achieved complete remission (CR),the overall CR rate was 51.7%,the CR rate of three different che- motherapy regimen being used were:COAP,16.7%(2/12);HOAP,53.1% (17/32);combination chemotherapy-LD-Ara-C,75%(12/16).The CR rate in HOA.P group and combination chemothrapy-LD-Ara-C group were signifi- cantly and quite significantly higher than that in COAP group respectively (P<0.05 and P<0.01 respectively).These results suggest that both HOAP and combination chemotherapy-LD-Ara-C regimen were as effective regimen for the remission-induction of ANLL.The CR rate was significantly higher in cases with peripheral white count <20×10~9/L or platelet count >40×10~9/L prior to chemotherapy than those with white count >20×10~9/L or platelet Count<40×10~9/L(P<0.05).In addition,active supporting treatment including blood transfusion,antibiotics and the traditional chinese medicine were also very important in getting a better CR rate.

关键词(KeyWords): 急性非淋巴细胞白血病;诱导缓解
Acute nonlymphocytic leukemia;Iuduction remission

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作者(Author): 李卓江;景本年;晏家益;李继勋;张继恺;周力;
Li Zhuojiang,Department of Internal Medicine

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