陈晓霞;王莉;王鉴;
CHEN Xiao-xia,WANG Li,WANG Jian(Neonatal Ward,Department of Pediatrics,The Affiliated Hospital of Guiyang Medical College,Guiyang 550004,China)

• 1:贵阳医学院附院新生儿病房
• 2:贵阳医学院附院新生儿病房
• 3:贵阳医学院附院新生儿病房 贵州贵阳550004
• 4:贵州贵阳550004贵阳医学院研究生

摘要(Abstract)：

目的:探讨窒息新生儿血中胃泌素(gastrin,GAS)和胃动素(motilin,MOT)的变化及其与胃肠道功能紊乱间的关系。方法:放射免疫法检测窒息新生儿生后1,3,7d空腹静脉血中GAS,MOT水平,并设对照组。结果:窒息新生儿第1天血GAS,MOT明显高于对照组,差异有统计学意义(P<0.05);第3,7dGAS基本接近对照组,差异无统计学意义(P>0.05),MOT低于对照组,但无统计学差异(P>0.05)。窒息组18例患儿中有10例发生不同程度的胃肠道功能紊乱,其第1,3天血GAS分别为(335.51±67.41)ng/L和(287.98±58.06)ng/L,与8例未发生胃肠道功能紊乱患儿的(265.23±42.31)ng/L,(234.01±47.11)ng/L相比较明显升高,其中以第1天尤为显著,有统计学意义(P<0.05);第1,3天血中MOT水平分别为(182.71±73.37)ng/L和(143.75±46.79)ng/L,均低于未发生胃肠功能障碍患儿的(215.37±79.69)ng/L和(170.08±48.14)ng/L,但尚无统计学意义(P>0.05)。结论:窒息新生儿GAS和MOT分泌异常可能与胃肠道功能紊乱有关。
Objective:To explore the content changes of plasma gastrin(GAS)and motilin(MOT)in asphyxial neonates and relationship between the changes and gastrointestinal dysfunction.Methods:Contens of GAS and MOT in venous plasma of fasting blood of asphyxial neonates were measured on the first day,third day,and seventh day after the birth by radioimmuno assay.Control group was set up with healthy neonates.Results:The plasma levels of GAS and MOT of asphyxial group were higher than those of control group on the first day,and the differences were statistically significant(P<0.05).On the third and seventh days,the plasma GAS levels of the two groups were similar,while the plasma MOT levels in asphyxial group were lower than those of control,although the difference was not statistically significant(P>0.05).Ten of the 18 asphyxial neonates had gastrointestinal dysfunction,and their plasma GAS levels on the first day and the third day were(35.51 ±67.41)ng/L,and(287.98±58.06)ng/L respectively,which were higher than those of neonates without gastrointestinal dysfunction(265.23±42.31)ng/L,(234.01±47.11)ng/L.Especially,the GAS level difference of the two groups on the first day was statistically significant(P<0.05).The plasma MOT levels of neonates with gastrointestinal dysfunction were(182.71±73.37)ng/L,and(143.75±46.79)ng/L,which were lower than those of asphyxial neonates without gastrointestinal dysfunction(215.37 ±79.69)ng/L,(170.08±48.14)ng/L,but the differences were not statistically significant(P>0.05).Conclusion:Parasecretion of GAS and MOT in asphyxial neonates might correlate with gastrointestinal dysfunction.

关键词(KeyWords)： 窒息,新生儿;胃肠疾病;胃泌素类;放射免疫检测;胃动素
asphyxia neonatorum;gastrointestinal diseases;gastrins;radioimmunodetection;motilin

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 陈晓霞;王莉;王鉴;
CHEN Xiao-xia,WANG Li,WANG Jian(Neonatal Ward,Department of Pediatrics,The Affiliated Hospital of Guiyang Medical College,Guiyang 550004,China)

Email:

DOI: 10.19367/j.cnki.1000-2707.2006.05.015

参考文献(References)：

• [1]Alfredo Guarion,Giulio De Marco.Natural history of intes-tinal failure,investigated through a national network-basedapproach[J].J of Pediatric Gastroenterology and Ntri-tion,2003(124):1615-1628.
• [2]李自普,李堂,张秋业,等.小儿胃肠功能衰竭的早期诊断和预后[J].小儿急救医学,2000,15(4):197-198.
• [3]田德峰,王彦辉,任慧霞.胃肠激素的研究概况[J].中国生化药物杂志,2000,21(6):316-318.
• [4]Andrea Varro,Toy ESArdill.An Analytical Review[J].Annals of ClinicalBiochemistry,2003,40(5):472.
• [5]Ordaz-Jimenez MR,Fernandez-Celis JM,Rivera-Rosas S,etal.Gastrointestinal hormones during minimal enteral feed-ing of sick premature infants[J].Rev Invest Clin,1998(50):37-42.
• [6]唐红敏.窒息后新生儿血中胃肠激素水平的动态观察[J].新生儿科杂志,1998,14(6):255.
• [7]Kirton CM,Wang T,Dockray GJ.Regulation of parient cell migration by gastrin in the mouse[J].Am J Physiol Gas-tronintest Liver Physiol,2002,283(3):787-793.

文章评论(Comment)：