贵州医科大学学报

1994, (03)

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不同剂量顺铂的PV方案综合治疗鼻咽癌114例临床分析
Treatment of Nasopharyngeal Carcinoma in 114 Cases by Different Dose of Cisplatin Combined with VCR and Radiotherapy

吴庆芬,卢泰棋
Wu Qingfen;et al (Department of Cancer,Guiyang Medical College)

摘要(Abstract):

报道瓜剂量(20mg/d×5)与中剂量(50mg/d×2)顺铂加长春新碱(VCR)(1.5mg/dd1,8)的PV方案与常规放疗联合应用治疗鼻咽癌114例。其中,低剂量顺铂组73例,中剂量顺铂组41例,两组综合治疗(PV加放疗)有效率分别为93.1%及97.5%,但统计学处理差异无显著性,两组病例化疗后的毒副反应发生率差异也无显著性,但中剂量组具有方法简便,患者易于接受的优点,可作为NPC的辅助化疗。
Hundred and fourteen patients with nasopharyngeal carcinoma were treated.The patients were devided into two groups.A group patients(73 cases) were treated by medium-dose DDP(DDP 50mg/d×2),plus VCR(1.5mg/g d 1,8) and radiotherapy.B group patients(41 cases) were treat by low-dose DDP (DDP 20mgl/d×5).Results:The active rate(CR+PR) in A and B group were 97.5% and 93.1% respectively (P>0.05).The incidence of leucopennia,vomitus and nephrotoxicity was no significant difference in the two groups(P>0.05).But the method was simple and easily accepted by patients in the B group.It is indicated that the method of medium-dose group may be as an assistant method in the basopharyngeal chemotherapy.

关键词(KeyWords): 顺铂,鼻咽肿瘤,联合药物疗法
cisplatin;nasopharyngeal neoplasms;drug therapy combirnation

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作者(Author): 吴庆芬,卢泰棋
Wu Qingfen;et al (Department of Cancer,Guiyang Medical College)

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DOI: 10.19367/j.cnki.1000-2707.1994.03.009

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