贵州医科大学学报

2007, No.128(05) 496-498

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视网膜脱离伴脉络膜脱离者外周血炎症相关细胞因子的含量
The Peripheral Blood Levels of Helper T Lymphocyte 1 Cytokines in Patients with Rhegmatogenous Retinal Detachment Associated with Choroidal Detachment

于旭辉;葛红岩;张蕾;宋晗;遇颖;王宇虹;
YU Xuhui1,GE Hongyan1,ZHANG Lei1,SONG Han1,YU Ying1,WANG Yuhong2(1.Department of Ophthalmology,The First Clinical College of Harbin Medical University,Haerbin 150001,Heilongjiang,China;2.Department of Neurology,The First Clinical College of Harbin Medical University,Haerbin 150001,Heilongjiang,China)

摘要(Abstract):

目的:系统监测视网膜脱离伴脉络膜脱离(脉脱型网脱)患者外周血中促炎细胞因子IL-12和IL-18,抑炎细胞因子IL-4和IL-10以及炎细胞效应因子IFNγ-和TNFα-的含量。方法:选取脉脱型网脱患者23例,正常对照组19例,分别采集患者和健康对照者的外周静脉血,用酶联免疫吸附方法(EILSA)检测IL-12、IL-18、IL-4、IL-10、TNFα-和IFNγ-的表达水平。结果:脉脱型网脱患者外周血中IL-12及IFNγ-、TNFα-的含量显著高于对照组(P<0.05),IL-10显著低于对照组(P<0.05),IL-18和IL-4的变化不明显(P>0.05)。结论:在脉脱型网脱中,促炎因子IL-12表达增高,抑炎因子IL-10的表达降低,同时效应炎性因子TNFα和IFNγ均显著增高,表明Th1介导的炎性损伤在脉脱型网脱的病程中有重要作用。
Objective: To systemically monitor levels of cytokines including proinflammatory cytokines IL-12 and IL-18,antinflammatory cytokines IL-4 and IL-10,and inflammatory cell effect cytokines IFN-γ and TNF-α in peripheral blood of patients with rhegmatogenous retinal detachment associated with choroidal detachment.Methods: Serum cytokines(intergeron IFN-γ,TNF-α,interleukin IL-4,IL-10,IL-18 and IL-12) levels in 23 patients suffering from rhegmatogenous retinal detachment associated with choroidal detachment and 19 healthy controls were measured by using sandwich ELISA.Results: Higer levels of IFN-γ,TNF-α and IL-12 and lower levels of IL-10 were found in serum samples from patients than in those of controls(P<0.05).No difference was found between IL18 or IL-4 levels of patients and healthy controls.Conclusion: Inflammatory damage mediated by helper T lymphocyte 1 might play an important role in the developing course of retinal detachment associated with choroidal detachment.

关键词(KeyWords): 视网膜脱离;细胞因子类;酶联免疫吸附测定;视网膜脱离伴脉络膜脱离
retinal detachment;cytokines;enzyme-linked immunosorbent assay;choroidal detachment associated with retinal detachment

Abstract:

Keywords:

基金项目(Foundation): 黑龙江省卫生厅医学科研专题资助项目项目编号2006-018;; 黑龙江省攻关国际合作项目项目编号WC05C04

作者(Author): 于旭辉;葛红岩;张蕾;宋晗;遇颖;王宇虹;
YU Xuhui1,GE Hongyan1,ZHANG Lei1,SONG Han1,YU Ying1,WANG Yuhong2(1.Department of Ophthalmology,The First Clinical College of Harbin Medical University,Haerbin 150001,Heilongjiang,China;2.Department of Neurology,The First Clinical College of Harbin Medical University,Haerbin 150001,Heilongjiang,China)

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DOI: 10.19367/j.cnki.1000-2707.2007.05.015

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