贵州医科大学学报

2016, v.41;No.186(03) 326-329

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贵州省119例肺结核耐药的危险因素分析
Analysis on the Risk Factors of Drug Resistance in 119 Cases of Pulmonary Tuberculosis in Guizhou Province

杨文婷;廖江荣;张先明;程义局;王云;文学;杜娟;
YANG Wenting;LIAO Jiangrong;ZHANG Xianming;CHEN Yiju;WANG Yun;WEN Xue;DU Juan;Respiratory Department,Guizhou Medical University;Respiratory Department,Guizhou Aerospace Hospital;

摘要(Abstract):

目的:探讨贵州省119例肺结核发生耐药的相关危险因素。方法:收集贵州省中部地区119例耐药的肺结核患者(耐药组)和150例非耐药的肺结核患者(非耐药组)的临床资料(性别、年龄、居住地、初/复治、治疗过程是否中断、是否合并糖尿病以及胸部CT是否有空洞)进行统计学处理,把有统计学意义的因素行多因素非条件Logistic回归分析,探讨肺结核发生耐药的相关危险因素。结果:肺结核耐药的发生与患者的性别、年龄无关(P>0.05),与居住地、初/复治、治疗过程是否中断、是否合并糖尿病、胸部CT是否有空洞有关(P<0.01);多因素非条件Logistic回归分析显示,居住地为农村(OR=0.261,95%CI=0.138~0.469)、复治(OR=3.094,95%CI=1.638~5.846)、治疗过程中断(OR=3.156,95%CI=1.707~5.835)、合并糖尿病(OR=3.806,95%CI=1.832~7.907)、胸部CT有空洞(OR=3.501,95%CI=1.884~6.506)是肺结核发生耐药的相关危险因素。结论:居住地为农村、复治、治疗过程中断、合并糖尿病及胸部CT有空洞的肺结核患者易出现耐药性。
Objective: To investigate the risk factors of drug resistance of 119 cases of pulmonary tuberculosis in Guizhou province. Methods: Clinical information( gender,age,place of residence,beginning / retreatment,wether the course of treatment was interrupted,whether complicated with diabetes and chest CT showed cavity) of 119 cases of drug-resistant pulmonary tuberculosis patients( resistance group) and 150 cases of non drug resistant pulmonary tuberculosis patients( non resistance group) in central region of Guizhou province was collected and statistically analyzed. Multivariate non conditional Logistic regression analysis was performed to analyze the statistically significant factors to find the related factors of drug resistance of pulmonary tuberculosis. Results: Drug resistance of pulmonary tuberculosis was not associated with gender and age,but it was related to place of residence,beginning / retreatment,wether the course of treatment was interrupted,whether complicated with diabetes and chest CT showed cavity. Multivariate non conditional Logistic regression analysis showed that residence place was rural area( OR = 0. 261,95% CI = 0. 138 ~ 0. 469),retreatment( OR = 3. 094,95% CI = 1. 638 ~ 5. 846),the course of treatment was interrupted( OR = 3. 156,95% CI = 1. 707 ~5. 835),complicated with diabetes( OR = 3. 806,95% CI = 1. 832 ~ 7. 907),chest CT showed cavity( OR = 3. 501,95% CI = 1. 884 ~ 6. 506) were the related factors of drug resistance of pulmonary tuberculosis. Conclusion: Drug resistance is prone to happen in pulmonary tuberculosis patients having following risk factors: residence place is rural area,retreatment,the course of treatment is interrupted,complicated with diabetes,chest CT showed cavity.

关键词(KeyWords): 结核,肺;耐药;危险因素;糖尿病;贵州
tuberculosis,pulmonary;drug resistance;risk factors;diabetes;Guizhou

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作者(Author): 杨文婷;廖江荣;张先明;程义局;王云;文学;杜娟;
YANG Wenting;LIAO Jiangrong;ZHANG Xianming;CHEN Yiju;WANG Yun;WEN Xue;DU Juan;Respiratory Department,Guizhou Medical University;Respiratory Department,Guizhou Aerospace Hospital;

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DOI: 10.19367/j.cnki.1000-2707.2016.03.024

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