贵州医科大学学报

2006, (05) 403-405

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头孢他美酯的合成实验研究
An Experimental Study on Synthesis of Cefetamet Pivoxil

罗喜荣;蒋翠兰;罗小美;
LUO Xi-rong1,JIANG Cui-lan2,LUO Xiao-mei3(1.Department of Organic Chemistry,Guiyang Medical College,Guiyang 550004,China;2.Hebei Provincial Professional Technology College of Chemistry-Industry Medicing,Shijiazhuang 050031,Hebei,China;3.The Second People's Hospital of Tongren District,Tongren 554300,Guizhou,China)

摘要(Abstract):

目的:探讨以头孢他美与特戊酸碘甲酯为原料,合成头孢他美特戊酰氧甲酯路线的可行性,研究原料配比、催化剂、反应温度、反应时间等因素对实验结果的影响。方法:在极性非质子性溶剂N,N-二甲基甲酰胺溶液中,在一定反应温度和反应时间下,用碱作催化剂,以头孢他美与特戊酸碘甲酯为原料,合成头孢他美特戊酰氧甲酯,并优化反应条件。结果:在极性非质子性溶剂N,N-二甲基甲酰胺溶液中,在三乙胺催化下,反应温度20~23℃,以头孢他美与特戊酸碘甲酯为原料,合成头孢他美特戊酰氧甲酯的路线是最佳合成路线,收率可达84%。结论:原料配比、碱、反应温度、反应时间等因素对产品质量、色泽、收率有很大影响。
Objective:To investigate the synthesis route of cefetamet pivoxil from iodomethyl pivalate and cefetamet and affecting factors.Methods:Cefetamet pivoxil was synthesized from iodomethyl pivalate and cefetamet in the N,N-dimethylformamide solution,with the presence of base and at 0-40 ℃.Results:Optimum conditions for cefetamet pivoxil synthesis was summarized that the ratio of iodomethyl pivalate to cefetamet was 0.5∶1 in the N,N-dimethylformamide solution,with the presence of Et3N,and the reaction temperature was 20-23 ℃.The objective compound was obtained by 84% of the total yield.Conclusion:Quality,color and yield of cefetamet pivoxil are affected by material ratio,catalyst,temperature and reaction time.

关键词(KeyWords): 抗生素类;温度;时间;碱类;特戊酸碘甲酯;头孢他美酯
antibiotics;temperature;time;alkalies;iodometyl pivalate;cefetamet pivoxil

Abstract:

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作者(Author): 罗喜荣;蒋翠兰;罗小美;
LUO Xi-rong1,JIANG Cui-lan2,LUO Xiao-mei3(1.Department of Organic Chemistry,Guiyang Medical College,Guiyang 550004,China;2.Hebei Provincial Professional Technology College of Chemistry-Industry Medicing,Shijiazhuang 050031,Hebei,China;3.The Second People's Hospital of Tongren District,Tongren 554300,Guizhou,China)

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DOI: 10.19367/j.cnki.1000-2707.2006.05.007

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