贵州医科大学学报

2005, (03) 239-240+243

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急性脑梗死患者血清神经特异性烯醇化酶的含量及杏丁的影响
The Variation of Serum Content of Nerve Specific Enolase in Patients with Acute Cerebral Infarction and The Influence of Xingding on It

赵萍,龚玲,杜立,付蓉,柴雪梅
ZHAO Ping, GONG Ling, DU Li, FU Rong, CHAI Xue-mei (The second people’s hospital of Guiyang, Guiyang 550002, China)

摘要(Abstract):

目的:探讨急性脑梗死患者血清神经特异性烯醇化酶(NSE)的含量变化及杏丁对其的影响。方法:观察急性脑梗死患者在发病3d内和治疗1周后血清NSE变化和神经功能缺损评分变化,并观察杏丁对其的影响。结果:急性脑梗死常规治疗组和杏丁组发病2d内血清NSE均高于对照组(P<0.01)。治疗1周后常规治疗组血清NSE含量仍高于对照组(P<0.05),而杏丁组与对照组之间差异无显著性(P>0.05);杏丁组神经功能缺损评分与常规治疗组相比差异有显著性(P<0.05)。结论:急性脑梗死患者血清NSE含量增高,而杏丁可显著降低NSE的含量;杏丁的近期临床疗效也优于常规治疗组。表明杏丁对急性脑梗死患者具有脑保护作用。
Objective: To investigate the variation of serum content of nerve specific enolase (NSE) in patients with acute cerebral infarction (ACI) and the influence of xingding on it. Methods: To observe the changes of NSE content in serum and nerve function deficit score of patients with ACI in the first 3 days of the onset and one week post-treatment. The results of patients in Xingding treated group (XG) were compared with those of patients in routine treated group (RG). 30 healthy people were chosen as control group. Results: NSE contents of patients in both XG group and RG group in the first 2 days were higher than those of control group ( P< 0.01). In one week post-treatment, NSE content of patients in RG group was still higher than that of control group ( P< 0.05), while that of XG group decreased to the level of control group ( P >0.05), and the nerve function deficit score of XG group was significantly different from that of control group. Conclusions: The NSE content in serum increases in patients with ACI. Xingding can decrease its level. Xingding gives better curative results than routine therapy in a short period, which shows that Xingding has protective effect to brain.

关键词(KeyWords): 脑梗塞;二裂银杏;磷酸丙酮酸水合酶;神经特异性烯醇化酶;杏丁
brain injuries; ginkgo biloba; phosphophruvate hydratase; nerve specific enolase; xingding

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作者(Author): 赵萍,龚玲,杜立,付蓉,柴雪梅
ZHAO Ping, GONG Ling, DU Li, FU Rong, CHAI Xue-mei (The second people’s hospital of Guiyang, Guiyang 550002, China)

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