贵州医科大学学报

2019, v.44;No.223(04) 423-426+452

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纤维蛋白原Bβ链HinfⅠ基因多态性与胃癌的相关性
Relevance between Fibrinogen β Chain- HinfⅠGene Polymorphisms and Gastric Cancer

严芝强;杨芳;
YAN Zhiqiang;YANG Fang;Affiliated Hospital of Guizhou Medical University;Guizhou Medical University;

摘要(Abstract):

目的:探讨纤维蛋白原B(FgB)β链-HinfⅠA/C基因多态性与胃癌的相关性。方法:151例经病理确诊的胃癌患者为胃癌组,151例同期健康体检者为对照组,采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)技术检测2组受检查全血DNA FgBβ-HinfⅠ位点基因型,比较两组受粒者FgBβHinfⅠC基因多态性,分析FgBβHinfⅠC基因型分布与胃癌的临床分期及转移的关系,采用logistic回归分析FgBβHinfⅠC基因型与胃癌的相对危险度。结果:FgBβHinfⅠA/C位点AA、AC、CC基因型分布及A/C等位基因频率与正常对照组比较差异具有统计学意义(P<0.05),FgBβHinfⅠA/C位3种基因型分布和等位基因频率与胃癌的临床分期及转移比较,差异无统计学意义(P>0.05);FgBβHinfⅠA/C位点AC基因型与胃癌的相对危险度分析,结果显示,OR=1.888、95%置信区间CI为1.105~3.224。结论:FgBβ-HinfⅠA/C的AC基因型可能增加胃癌的发病风险,C等位基因可能是胃癌发病的致病基因。
Objective: To investigate relevance between Fibrinogen B beta chain-HinfⅠgene polymorphism and gastric cancer. Methods: 151 cases of pathological diagnosed gastric cancer patients as gastric cancer group, and 151 cases of healthy physical check takers as control group; the polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) technology was adapted to detect Fibrinogen beta chain-HinfⅠ site genotype. Results: Gastric cancer group fibrinogen beta beta-Hinf I A/C locus AA, AC, CC genotype distribution and A/C allele frequency showed significant difference with normal control group(P<0.05); Fibrinogen beta-HinfIA/C locus of three kinds of genotype distribution and allele frequency was compared with clinical staging and transfer of gastric cancer, comparison was statistically significant(P>0.05); analysis between Fibrinogen beta-HinfI A/C locus AC genotype and relative risk degree of gastric cancer showed odds ratio(OR) as 1.888 and 95% confidence interval(CI) between 1.105 and 3.224. Conclusions: FgB beta Hinf Ⅰ AC of the A/C genotype may increase the risk of gastric cancer, C allele may be disease genes of gastric cancer.

关键词(KeyWords): 胃肿瘤;纤维蛋白原;基因;多态性,限制性片段长度
gastric neoplasm;fibrinogen;gene polymorphism;restriction fragment length

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基金项目(Foundation): 贵州省科技厅联合基金[黔科合LJ(2016)7235号]

作者(Author): 严芝强;杨芳;
YAN Zhiqiang;YANG Fang;Affiliated Hospital of Guizhou Medical University;Guizhou Medical University;

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DOI: 10.19367/j.cnki.1000-2707.2019.04.009

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