贵州医科大学学报

1991, (04) 358-360

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肝肾综合征患者血浆肾素活性、血管紧张素Ⅱ水平测定的临床意义
Significance of the Plasma Renin and Angietensin Ⅱ Determinations in Hepatorenal Syndrome

周力;佃雪辉;张文田;李培;卢源;姚淙;
Zhou Li, et al Department of Internal Medicine

摘要(Abstract):

本文作者用放射免疫法测定了9例肝肾综合征及17例无氮质血症的肝硬化患者的血浆肾素活性、血管紧张素Ⅱ含量。结果表明肝肾综合征患者的血浆肾素活性、血管紧张素Ⅱ明显高于无氮质血症组及正常对照组,提示患者血浆中这二种物质的增高与肝肾综合征的发病机理相关。作者提出肾素活性≥16.4mol.L 1/h的肝硬化患者有可能发生肝肾综合征。
The plasma renin activity (PRA)and angiotensin Ⅱ(AT Ⅱ) levels were tested using RIA in 9 patients with hepatorenal syndrome and 17 patients with decompensated cirrhosis without azotemia. The PR and AT Ⅱ levels in the former were 41.21±18.96mol·-~1L/h and 865.04±709.06ng/L, and those in the latter, 8.01±9.75 and 204.98±235.40(mean±SD), respectively. The significantly higher PR and AT Ⅱ levels in the former suggested their relation with the pathogenesis of hepatorenal syndrome. A PRA higher than 16.4mol·L~(-1)/h in the patients with cirrhosis suggested a risk of hepatorenal syndrome. Therefore, determination of PRA might help to evaluate the cirrhotic patients' prognosis.

关键词(KeyWords): 肝;肾;肾素;血管紧张素Ⅱ
liver; kidney; renin; angiotensin Ⅱ

Abstract:

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作者(Author): 周力;佃雪辉;张文田;李培;卢源;姚淙;
Zhou Li, et al Department of Internal Medicine

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DOI: 10.19367/j.cnki.1000-2707.1991.04.021

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