肝肾综合征患者血浆肾素活性、血管紧张素Ⅱ水平测定的临床意义Significance of the Plasma Renin and Angietensin Ⅱ Determinations in Hepatorenal Syndrome
周力;佃雪辉;张文田;李培;卢源;姚淙;
Zhou Li, et al Department of Internal Medicine
摘要(Abstract)：
本文作者用放射免疫法测定了9例肝肾综合征及17例无氮质血症的肝硬化患者的血浆肾素活性、血管紧张素Ⅱ含量。结果表明肝肾综合征患者的血浆肾素活性、血管紧张素Ⅱ明显高于无氮质血症组及正常对照组,提示患者血浆中这二种物质的增高与肝肾综合征的发病机理相关。作者提出肾素活性≥16.4mol.L 1/h的肝硬化患者有可能发生肝肾综合征。
The plasma renin activity (PRA)and angiotensin Ⅱ(AT Ⅱ) levels were tested using RIA in 9 patients with hepatorenal syndrome and 17 patients with decompensated cirrhosis without azotemia. The PR and AT Ⅱ levels in the former were 41.21±18.96mol·-~1L/h and 865.04±709.06ng/L, and those in the latter, 8.01±9.75 and 204.98±235.40(mean±SD), respectively. The significantly higher PR and AT Ⅱ levels in the former suggested their relation with the pathogenesis of hepatorenal syndrome. A PRA higher than 16.4mol·L~(-1)/h in the patients with cirrhosis suggested a risk of hepatorenal syndrome. Therefore, determination of PRA might help to evaluate the cirrhotic patients' prognosis.
关键词(KeyWords)：
肝;肾;肾素;血管紧张素Ⅱ
liver; kidney; renin; angiotensin Ⅱ
基金项目(Foundation):
作者(Author):
周力;佃雪辉;张文田;李培;卢源;姚淙;
Zhou Li, et al Department of Internal Medicine
Email:
DOI: 10.19367/j.cnki.1000-2707.1991.04.021
参考文献(References)：
- 1． 周力,等.肝碘化患者血浆心钠素、肾素活性、血管紧张素Ⅱ及醛固酮水平的初步研究.贵阳医学院学报1990;15(3) :301-304．
- 2． Hollenberg N K.肝病与肾脏.上海:上海翻译出版公司,1987:137 -143．
- 3． Epstein M.肝病与肾脏.上海:上海翻译出版公司,1987;118-130．
- 4． Wong PY, et al. Kallikrein-kinin and renin-angiotensin system in functional renal failure of cirrhosis of the liver. Gastroenterology 1977; 73(4) ; 1114．
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