贵州医科大学学报

1998, (04)

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脂蛋白(a)测定在肾疾病中的意义
The Clinical Significance of Measurement Lipoprotein (a) in Renal Disease

杨光,王锦支
Yang Guang, et al Clinical Laboratory, Affiliated Hospital Guiyang Medical College

摘要(Abstract):

为探讨肾疾病患者血清中脂蛋白(a)[Lp(a)]水平改变的临床意义及诊断价值,采用酶联法(ELISA),检测120例各种病理类型肾疾病患者血清中Lp(a)水平。结果表明:肾病综合征组、慢性肾功能衰竭组、急性肾炎组血清Lp(a)浓度显著高于对照组(P<001;P<001;P<005)。肾疾病患者Lp(a)水平与肾功能病变程度显著相关(P<001;P<005)。肾疾病患者血清中Lp(a)水平在一定程度上反映了Lp(a)可能在促进肾衰病人动脉硬化中具有重要作用,Lp(a)不仅是心,脑血管病的独立危险因素,且可作为肾疾病病变程度判断的一项有效指标
ELISA was used to measure serum lipoprotein a (Lpa) level in 120 cases with renal diseases to study the clinical significance and diagnosis value. The results indicated that Lpa level of nephrotic, chronic renal insufficency, and acute nephritis group was obviously higher than control group (P<0 05). The Lpa concentration of nephritis patients had obviously relationship with impairment of renal function(P<0 05). This study suggestes that the Lpa not only was the independent dangerous factor of heart and cerebrovascular disease, but also regarded as an effective indes of judging renal pathological change degree.

关键词(KeyWords): 肾疾病,脂蛋白类,酶联免疫吸附测定
kidney diseases; lipoproteins; enzyme-linked immunosorbent assay

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作者(Author): 杨光,王锦支
Yang Guang, et al Clinical Laboratory, Affiliated Hospital Guiyang Medical College

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