贵州医科大学学报

2018, v.43;No.211(04) 478-481

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维持性血液透析对患者血清降钙素原、白细胞介素-6及超敏C反应蛋白的影响
The Maintenance Hemodialysis on the Serum Procalcitonin,Interleukin-6and Hypersensitive C-reactive Protein of Patients

唐芳;张波;沈俊;
TANG Fang;ZHANG Bo;Sheng Jun;Nuclear Medicine Department,Hospital of Nuclear Industry 416;Urological Department,the Affiliated Hospital of Guizhou Medical University;

摘要(Abstract):

目的:探讨维持性血液透析(MHD)治疗对患者血清降钙素原(PCT)、白细胞介素-6(IL-6)及超敏C反应蛋白(hs-CRP)水平的影响。方法:选取90例行MHD治疗的患者作为透析组,90例同期健康体检者作为对照组,分别于对照组体检时、透析组MHD前和MHD 4 h时采集受试者静脉血,检测血清PCT、IL-6及hs-CRP水平;采用Pearson相关检验分析MHD前后血清PCT、IL-6及hs-CRP的相关性,通过建立相关的线性回归模型、评价其用于MHD并发感染的预测价值。结果:与对照组比较,透析组患者MHD前后血清PCT、IL-6及hs CRP水平显著高于对照组(P<0.05);与MHD前比较,透析组患者MHD后血清PCT及hs-CRP水平显著升高(P<0.05),透析组患者MHD后血清IL-6比较差异无统计学意义(P>0.05);Pearson相关分析结果显示,MHD前后血清PCT、IL-6及hs-CRP水平存在正相关关系(r=0.884、0.911、0.993,P<0.05);建立的线性回归模型PCT为Y=0.972X+0.132、IL-6为Y=0.883X+3.013,hs-CRP为Y=1.155X-0.282(P<0.01),提示线性回归模型可用于MHD并发感染指标的预测。结论:MHD患者血透前后血清PCT、IL-6和hs-CRP水平均高于健康人群,本研究建立的3项指标的线性回归模型可用于MHD并发感染时的动态监测。
Objective: To investigate how the maintenance hemodialysis( MHD) influences on the levels of serum procalcitonin( PCT),interleukin-6( IL-6),hypersensitive C-reactive protein( the hsCRP) of patients. Methods: To choose 90 patients with MHD treatment as the group of hemodialysis and 90 cases with healthy physical examination as the contrastive group from the nuclear industry hospital 416. And to collect the venous blood of subjects to test the levels of serum PCT,IL-6,hs-CRP when the contrastive group had physical examinations,before the group of hemodialysis got MHD and when MHD time was just up to 4 h. The correlation between the serum PCT,interleukin 6 and the hypersensitive C-reactive protein before and after MHD was analyzed by using Pearson correlation test and it was used to assess the predictive value of MHD concurrent infection by building relevant linear regression models. Results: To compare with the contrastive group,the levels of serum PCT,Il-6 and hs-CRP of the hemodialysis patients before and after MHD were distinctively higher than the contrastive group( P < 0. 05); and the levels increased distinctively after MHD compared with before( P <0. 05); but the differences between the two groups were statistically insignificant( P > 0. 05). Pearson relevant analytic results show that the serum PCT,IL-6,hs-CRP levels before and after MHD had positive correlation( r = 0. 884,0. 911,0. 993,P < 0. 05),and the built linear regression model PCT was Y = 0. 972 X + 0. 132,IL-6 was Y = 0. 883 X + 3. 013、hs-CRP was Y = 1. 155 X-0. 282,P < 0. 01,the hint linear regression model can be used in prediction of the MHD concurrent infection indexes. Conclusion: The serum PCT,IL-6,hs-CRP levels before and after hemodialysis of MHD patients were higher than those of healthy people,and linear regression models of these markers based on the research can be used for the dynamic monitoring in the process of infection treatment.

关键词(KeyWords): 血液透析;尿毒症;降钙素原;白细胞介素-6;超敏C反应蛋白;微炎症反应
maintenance hemodialysis;uremia;procalcitonin;interleukin-6;hypersensitive C-reactive protein;micro inflammation reaction

Abstract:

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基金项目(Foundation): 贵州医科大学博士启动基金(YJ2017-18)

作者(Author): 唐芳;张波;沈俊;
TANG Fang;ZHANG Bo;Sheng Jun;Nuclear Medicine Department,Hospital of Nuclear Industry 416;Urological Department,the Affiliated Hospital of Guizhou Medical University;

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DOI: 10.19367/j.cnki.1000-2707.2018.04.023

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