贵州医科大学学报

2016, v.41;No.188(05) 527-531

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云南汉族人群CD6基因多态性与HCV慢性感染的关系
The Association between CD6 Polymorphisms and Chronic HCV Infection of Han Population in Yunnan Province

刘城秀;沈云松;李桃意;张禹;檀林萍;姚月婷;俞建昆;姚宇峰;史荔;
LIU Chengxiu;SHEN Yunsong;LI Taoyi;ZHANG Yu;TAN Linping;YAO Yueting;YU Jiankun;YAO Yufeng;SHI Li;Institute of Medical Biology,Chinese Academy of Medical Sciences & Peking Union Medical College;Yunnan Key Laboratory of Vaccine Research & Development on Severe Infectious Disease;The First People's Hospital in Yunnan Province & the Affiliated Hospital of Kunming Science and Technology University;

摘要(Abstract):

目的:探讨云南汉族人群中CD6基因多态性与慢性丙型肝炎病毒(HCV)感染的关系。方法:随机抽取云南地区汉族人群HCV慢性感染患者434例,健康对照人群444例;采用TaqMan探针基因分型方法对2组人群的CD6基因3个SNPs(rs17824933、rs12360861、rs11230563)进行基因分型,构建CD6基因单倍型,评估上述3个SNPs与HCV慢性感染的关系。结果:两组人群CD6基因SNP-rs17824933(C>G)、SNP-rs12360861(G>A)和SNP-rs11230563(C>T)基因型频率和等位基因频率比较,差异无统计学意义(P>0.05);2组人群的SNP-rs17824933(C>G)、SNP-rs12360861(G>A)和SNP-rs11230563(C>T)单倍型频率比较,差异无统计学意义(P>0.05)。结论:此次调查的云南汉族群体的CD6基因SNP-rs17824933(C>G)、SNP-rs12360861(G>A)和SNP-rs11230563(C>T)与HCV慢性感染无关。
Objective: To investigate the association between CD6 gene polymorphism and chronic HCV chronic infection of Han population in Yunnan province. Methods: 434 HCV chronic infectious patients and 444 healthy individuals of Han Chinese population in Yunnan province were recruited for this study. Three single nucleotide polymorphisms( SNPs) of SNP-rs17824933,SNP-rs12360861 and SNP-rs11230563 of CD6 gene were determined by real-time TaqMan polymerase chain reaction and the haplotypes were constructed. Then evaluating the association correlation of these SNPs and haplotypes with HCV chronic infection. Results: The comparison of frequencies of allele and genotype of both groups of SNP-rs17824933( C > G),SNP-rs12360861( G > A) and SNP-rs11230563( C > T)showed that differences were not statistically significant( P > 0. 05). The frequency of haplotypes constructed by SNP-rs17824933( C > G),SNP-rs12360861( G > A) and SNP-rs11230563( C > T)showed no significant difference( P > 0. 05). Conclusion: SNP-rs17824933( C > G), SNPrs12360861( G > A) and SNP-rs11230563( C > T) in the CD6 were not associated with HCV chronic infection in the Han population in Yunnan province.

关键词(KeyWords): 肝炎,丙型,慢性;多态性单核苷酸;基因,CD6;云南
hepatitis C,chronic;polymorphism,single nucleotide;gene,CD6;Yunnan

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金(81160197);; 吴阶平医学基金(320.6750.13395)

作者(Author): 刘城秀;沈云松;李桃意;张禹;檀林萍;姚月婷;俞建昆;姚宇峰;史荔;
LIU Chengxiu;SHEN Yunsong;LI Taoyi;ZHANG Yu;TAN Linping;YAO Yueting;YU Jiankun;YAO Yufeng;SHI Li;Institute of Medical Biology,Chinese Academy of Medical Sciences & Peking Union Medical College;Yunnan Key Laboratory of Vaccine Research & Development on Severe Infectious Disease;The First People's Hospital in Yunnan Province & the Affiliated Hospital of Kunming Science and Technology University;

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DOI: 10.19367/j.cnki.1000-2707.2016.05.008

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