贵州医科大学学报

1994, (02)

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静脉注射受体阻断剂酚妥拉明、赛庚啶和纳洛酮对LRN下行性抑制作用的影响
The Effect of Intravenous Receptor Antaganists on the Descending Inhibition from LRN

伍国锋,陈婉梅,阎剑群
Wu Guofeng et al (Departmemt of Neurology, Guiyang Medical College)

摘要(Abstract):

本实验采用微电极细胞外记录方法,以清醒大鼠脊髓背角广动力范围(WDR)神经元的伤害性诱发放电频率(即晚串放电频率)为指标,观察静脉注射受体阻断剂酚妥拉明、赛庚啶及纳洛酮对延髓外侧网状核(LRN)下行抑制作用的影响。结果表明,刺激LRN对WDR神经元的下行抑制作用部分是通过NE和5-HT实现的,LRN的这种下行抑制作用可能并不涉及内源性阿片肽。
Recent studies have revealed that the lateral reticular nucleus(LRN) in the caudal nedulla oblongata plays a very important role in the descending inhibitory controls of nociception. The present study was designed to examine the effect of intravenous receptor antaganists on the descending inhibition from LRN by the method of recording unit discharges of WDR neurones in the rat spinal dorsal horn, 20 WDR neurones were studied. Intravenous phentolamine as well as cypraheptadine could attenucte the descending inhibition produced by LRN stimulation but naloxone had little effect, indicating that the stimulation-produced inhibition from LRN on WDR neurones is partly mediated by NE and 5-HT, and endogeneous opioid peptides appear not to be involved.

关键词(KeyWords): 受体阻断剂,延髓外侧网状核,广动力范围神经元
receptor antaganist; lateral reticular nucleus; wide dynamic range neurone

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 伍国锋,陈婉梅,阎剑群
Wu Guofeng et al (Departmemt of Neurology, Guiyang Medical College)

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DOI: 10.19367/j.cnki.1000-2707.1994.02.001

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