贵州医科大学学报

1991, (04) 319-321

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人血浆唾液酸含量与生物年龄的关系
The Relationship between the Blood Plasma Sialic Acid Content and Age of the Human Being

吴虹;陶建蜀;雷霆雯;
Wu Hong, et al Department of Biochmistry

摘要(Abstract):

用硫代巴比妥酸法检测新生儿(24例)、青年(20~35岁,17例)、中年(36~53岁,25例)、老年(60~68岁,23例)健康人群血浆唾液酸含量,发现随着生物年龄的增长,血浆唾液酸含量呈阶梯形上升趋势。因此,血浆唾液酸有可能成为一项老化的指标。
The healthy donors were divided into four groups: the neonate, the youth (20—35 years), the middle age(36-53 years) and the old age (60-68 years). The blood of the first one (neonate) was collected from the umbilical cord and that of the others by the vein's puncture before food intake in the morning. Heparin sodium was used as an anticoagulant. The plasma was gather ed after centrifugation and the sialic acid (SA) was measured with the method of Aminnoff. The values of SA were 46.59±1.51, 72.64±1.57, 72.17±1.96 and 81.06±1.98mg/100ml (SA/plasma, mean±SE) in the neonate(n=24), youth(n=17), middle age(n=25) and old age group (n=23), respectively. The analysis of varia nce revealed that the plasma SA of the neonate group was the lowest (P<0.01) and the old age one, the highest (P<0.01). There was no diffe rence between the middle age and the youth group(P>0.05). It seemde that as the human being got old, the plasma SA increased, altthough from the youth to middle gae it kept the same, almost unchanged. Therefore, the SA content of the plasma cound probably be used as an objective index of human aging.

关键词(KeyWords): 唾液酸;血浆;衰老
sialic acid; plasma; aging

Abstract:

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作者(Author): 吴虹;陶建蜀;雷霆雯;
Wu Hong, et al Department of Biochmistry

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DOI: 10.19367/j.cnki.1000-2707.1991.04.010

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