贵州医科大学学报

2016, v.41;No.192(09) 1071-1074

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趋化因子受体4在卵巢上皮性癌中的表达及意义
Expression and Significance of CXCR4 in Epithelial Ovarian Cancer

陈国庆;王兴新;訾聃;
CHEN Guoqing;WANG Xingxin;ZI Dan;Department of Gynaecology and Obstetrics,the Affiliated Hospital of Guizhou Medical University;Department of Gynaecology and Obstetrics,the People's Hospital of Weining County;

摘要(Abstract):

目的:观察卵巢上皮性癌(EOC)中趋化因子受体4(CXCR4)、细胞周期蛋白D1(Cyclin D1)、表皮生长因子受体(EGFR)和增殖细胞核抗原(Ki-67)的表达及其与临床病理特征间的关系。方法:应用免疫组化法检测40例卵巢上皮性癌(EOC组)组织和10例卵巢良性肿瘤组织(对照组)中CXCR4阳性表达率,同时检测EOC患者癌组织中Cyclin D1、EGFR和Ki-67表达水平,分析CXCR4、Cyclin D1、EGFR及Ki-67在EOC患者癌组织中的阳性表达率与患者年龄、组织学分级、是否有淋巴转移及TNM分期的关系,采用Spearman秩相关分析EOC患者癌组织中CXCR4表达与EGFR、Cyclin D1及Ki-67表达的相关性。结果:对照组中CXCR4的阳性表达率(20%)低于EOC组(57.50%),差异有统计学意义(P<0.05);EOC患者癌组织中的CXCR4的阳性表达率与EOC患者临床分期、组织学分级及有无淋巴转移有关(P<0.05),与年龄无关(P>0.05);EOC患者中Cyclin D1阳性表达率与临床分期、组织学分级有关(P<0.05),而与年龄、有无淋巴结转移无关(P>0.05);EGFR与Ki-67的过表达率与临床分期有关(P<0.05),而与年龄、组织学分级及有无淋巴转移无关(P>0.05);EOC患者癌组织中CXCR4的阳性表达与Cyclin D1的阳性表达、EGFR的过表达及Ki-67的过表达之间呈现正相关性(r=0.535、0.506、0.490,P<0.05)。结论:CXCR4、Cyclin D1、EGFR和Ki-67的联合检测对EOC的发生、预后判断、治疗选择有一定的参考意义。
Objective: To investigate the expression of CXCR4,Cyclin D1,EGFR and Ki-67 in epithelial ovarian cancer( EOC) and its relationship with clinical pathological features. Methods: 40 cases of patients with epithelial ovarian cancer( observation group) and 10 cases of patients with ovarian benign tumor( control group) were tested for the expression of CXCR4,Cyclin D1,EGFR and Ki-67 protein by SP immunohistochemical assay kit. Combined with the medical record data,the relationship between the 4 cytokines and the clinical pathological characteristics was analyzed. Meanwhile,the relationship between CXCR4 and the other 3 cytokines was also analyzed. Results: The positive expression rate of CXCR4 in the observation group were significantly higher than those in the control group( P < 0. 05). There were statistically significant differences in the positive expression rate of CXCR4 under different pathology parameters such as clinical stage,histological grade and lymph node metastasis( P < 0. 05). There were statistically significant differences in the positive expression rate of Cyclin D1 under different pathology parameters such as clinical stage,histological grade and lymph node me-tastasis( P < 0. 05). The over expression rates of Ki-67 and EGFR was significantly related to clinical stage( P < 0. 05). CXCR4 were positively correlated with the expression of Cyclin D1,EGFR and Ki-67 in epithelial ovarian cancer( P < 0. 05). Conclusion: The joint detection of CXCR4,Cyclin D1,EGFR and Ki-67 may have important reference significance in prognosis of EOC and the choice of treatment of EOC.

关键词(KeyWords): 卵巢肿瘤,上皮性;趋化因子受体4;细胞周期蛋白D1;表皮生长因子受体;免疫组织化学;染色法
ovarian tumor epithelial;chemokine receptor type 4;cell cycle protein D1;epidermal growth factor receptor;immunohistochemistry;staining method

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基金项目(Foundation): 贵州省科技厅联合基金[黔科合LG字(2011)032号]

作者(Author): 陈国庆;王兴新;訾聃;
CHEN Guoqing;WANG Xingxin;ZI Dan;Department of Gynaecology and Obstetrics,the Affiliated Hospital of Guizhou Medical University;Department of Gynaecology and Obstetrics,the People's Hospital of Weining County;

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