贵州医科大学学报

2011, v.36;No.148(01) 30-33

[打印本页] [关闭]
本期目录(Current Issue) | 过刊浏览(Past Issue) | 高级检索(Advanced Search)

中缝大核NO和5-HT对大鼠胃运动的影响
A Study on Impact of Nitrogen Monoxidum in Nucleus Raphes Magnus and Serotonin on Gastric Motility of Rats

王丹;
WANG Dan(Department of Life Science,Xian Culture and Science College,Xian 710065,Shanxi,China)

摘要(Abstract):

目的:研究中缝大核一氧化氮(NO)和五羟色胺(5-HT)对大鼠胃运动的影响。方法:采用SD大鼠中缝大核(NRM)微量注射药物,记录胃运动收缩的幅度和频率。结果:中缝大核微量注射5-HT,能明显增强胃运动;中缝大核内预先注入精氨酸(L-Arg),可完全反转5-HT对胃运动的增强效应;中缝大核内预先注入一氧化氮合酶抑制剂(L-NAME),对5-HT增强胃运动的作用无影响,与生理盐水和5-HT的效应无显著差异,胃收缩频率均无明显变化。结论:NRM微量注入5-HT对胃运动有显著加强作用,NO可调制5-HT的作用。
Objective:To study the impact of nitrogen monoxidum(NO) in nucleus raphes magnus(NRM) and serotonin(5-HT) on gastric motility in rats.Methods: To record amplitude and frequency of gastric contraction in SD rats after micro-injection of NO and 5-HT in NRM.Result: Injection of 5-HT into NRM increased the amplitude of gastric contraction;Injection of L-Arg into NRM in advance could reverse the increase effect of 5-HT;Injection of an inhibitor of NO synthethase,L-NAME,into NRM in advance caused no change of the effect of 5-HT,and showed no remarkable difference from the effect of normal saline or 5-HT.Conclusions: The Injection of 5-HT into NRM could increase the amplitude of gastric contraction,and NO could regulate the effect of 5-HT on gastric motility.

关键词(KeyWords): 中缝核;胃;一氧化氮;大鼠,Sprague-Dawley;五羟色胺;胃运动;中缝大核
raphe nuclei;stomach;nitric oxide;rats sprague-dawley;serotonin;gastric motility;nucleus raphes magnus

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 王丹;
WANG Dan(Department of Life Science,Xian Culture and Science College,Xian 710065,Shanxi,China)

Email:

DOI: 10.19367/j.cnki.1000-2707.2011.01.010

参考文献(References):

文章评论(Comment):

序号(No.) 时间(Time) 反馈人(User) 邮箱(Email) 标题(Title) 内容(Content)
反馈人(User) 邮箱地址(Email)
反馈标题(Title)
反馈内容(Content)
扩展功能
本文信息
服务与反馈
本文关键词相关文章
本文作者相关文章
中国知网
分享