魏宏琳;宋宇峰;
WEI Honglin,SONG Yufeng(Department of Oral and Maxillafacial Surgery,The Affiliated Hospital of Guiyang Medical College,Guiyang 550004,China)

• 1:贵阳医学院附属医院口腔颌面外科
• 2:现在贵阳市妇幼保健院
• 3:贵阳医学院附属医院口腔颌面外科 贵州贵阳550004
• 4:贵州贵阳550004

摘要(Abstract)：

目的:了解口腔鳞癌(oral squamous-cell carcinoma,OSCC)组织及转移淋巴结中组织因子(tissue fac-tor,TF)的表达情况,探讨TF在OSCC发展和转移中的作用。方法:应用免疫组织化学SABC方法,检测了42例OSCC、15例转移淋巴结和10例正常口腔黏膜中TF的表达情况,分析TF与OSCC发展和转移的关系。结果:(1)在OSCC组织和淋巴结中TF的阳性表达分别为64.29%和67.78%,显著高于在正常口腔黏膜组织中的表达(10.00%,P<0.01);(2)TF与肿瘤的淋巴结转移、临床分期密切相关(P<0.01)。结论:OSCC中TF的表达上调对肿瘤的生长、发展和转移有促进作用,但其是否可作为反映OSCC生物学行为的客观指标仍有待研究。
Objective: To observe the expression of tissue factor(TF)in oral squamous-cell carcinoma(OSCC)tissue and metastasis lymph nodes,and to study its effect in the development and metastasis of OSCC.Methods: The expression of TF was detected with immunohistochemistry SABC method in tissue specimens of 42 cases of human OSCC,15 cases of metastasis lymph node and 10 normal oral mucosa,and the relationship between TF and the development and metastasis of OSCC was analyzed.Results:(1)TF expression rates in OSCC tissues and lymph nodes were 64.29%and 67.78% respectively,which were significantly higher than that in normal oral mucosa tissue(10.00%;P<0.01);(2)TF expression correlated with lymph node metastasis and TNM stage of OSCC(P<0.01).Conclusions: The expression up-regulating of TF in OSCC might have promoting effects to the growth,development and metastasis of OSCC.Further research is needed to prove weather TF can be used as an index to reflect the biological characteristics of OSCC.

关键词(KeyWords)： 癌,鳞状细胞;口腔肿瘤;免疫组织化学;肿瘤转移;组织因子
carcinoma,squamous cell;mouth neoplasms;immunohistochemistry;neoplasm metastasis;tissue factor

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金(30660200);; 贵州省省长专项资金项目(2005)160号

作者(Author): 魏宏琳;宋宇峰;
WEI Honglin,SONG Yufeng(Department of Oral and Maxillafacial Surgery,The Affiliated Hospital of Guiyang Medical College,Guiyang 550004,China)

Email:

DOI: 10.19367/j.cnki.1000-2707.2007.05.002

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