取代苯甲醛类Schiff碱型γ-氨基丁酸酯类化合物的合成Synthesis of Schiff Bases of γ-Aminobutyrates
袁牧;钟裕国;庞其捷;李正化;
Yuan Mum,et al Department of Pharmaceutical Chemistry
摘要(Abstract)：
作者以取代苯甲醛作为γ-氨基丁酸的亲脂性载体,设计并合成了3个取代苯甲醛类Schiff碱型γ-氨基丁酸酯类化合物作为抗惊厥化合物供药理筛选。所合成的目标化合物尚未见文献报道。
Most studies have indicated that γ-aminobutyric acid (GABA) plays a role in the pathophysiology of epilepsy. Under physiological conditions it is very difficult for GABA to cross the blood-brain barrier. It is likely that the pro-drugs of GABA, which easily enter the brain, will haveuseful therapeutic properties. With this in mind, we have designed and synthesized 3 derivatives of GABA with an imine to link a lipophilic carrier (Ⅳa to Ⅳc). These compounds have not been reported, their chemical structure were primarily indentified with IR Spectra.
关键词(KeyWords)：
γ-氨基丁酸衍生物;Schiff碱型;γ-氨基丁酸酯
Y-aminobutyric acid derivatives; Schiff bases of γ-aminobutyrates
基金项目(Foundation):
作者(Author):
袁牧;钟裕国;庞其捷;李正化;
Yuan Mum,et al Department of Pharmaceutical Chemistry
Email:
DOI: 10.19367/j.cnki.1000-2707.1991.04.003
参考文献(References)：
- 1． Enna SJ, et al. Biochemical pharmacology of GABAergic agonists. Life Sci 1979; 24: 1727～1738．
- 2． A. V Christensen and P Krogsaard-Larsen. GABA Agonists: Molecular and Behavioural Pharmacology. In: R G Farriello, et al. Neurotransmitters, Seizures, and Epilepsy Ⅱ. New york: Raven Press, 1984: 109-121．
- 3． Hayashi T. The inhibitory action of γ-aminobutyric acid upon the seisuk following stimulation of motor cortex of the dog. J physiol 1959; 145: 570．
- 4． Chase T N and Walters J R. In: Roberts E, et al. GABA in Nervous System Function. New York: Raven Press, 1976: 497．
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