贵州医科大学学报

1991, (04) 294-296

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取代苯甲醛类Schiff碱型γ-氨基丁酸酯类化合物的合成
Synthesis of Schiff Bases of γ-Aminobutyrates

袁牧;钟裕国;庞其捷;李正化;
Yuan Mum,et al Department of Pharmaceutical Chemistry

摘要(Abstract):

作者以取代苯甲醛作为γ-氨基丁酸的亲脂性载体,设计并合成了3个取代苯甲醛类Schiff碱型γ-氨基丁酸酯类化合物作为抗惊厥化合物供药理筛选。所合成的目标化合物尚未见文献报道。
Most studies have indicated that γ-aminobutyric acid (GABA) plays a role in the pathophysiology of epilepsy. Under physiological conditions it is very difficult for GABA to cross the blood-brain barrier. It is likely that the pro-drugs of GABA, which easily enter the brain, will haveuseful therapeutic properties. With this in mind, we have designed and synthesized 3 derivatives of GABA with an imine to link a lipophilic carrier (Ⅳa to Ⅳc). These compounds have not been reported, their chemical structure were primarily indentified with IR Spectra.

关键词(KeyWords): γ-氨基丁酸衍生物;Schiff碱型;γ-氨基丁酸酯
Y-aminobutyric acid derivatives; Schiff bases of γ-aminobutyrates

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 袁牧;钟裕国;庞其捷;李正化;
Yuan Mum,et al Department of Pharmaceutical Chemistry

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DOI: 10.19367/j.cnki.1000-2707.1991.04.003

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