贵州医科大学学报

2008, No.131(02) 159-161

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血尿酸水平与老年高血压患者颈动脉硬化关系探讨
A Study on the Relationship between Serum Uric Acid Level and Carotid Atherosclerosis in Elderly Hypertension Patients

杨俊;唐海滨;胡艳文;贾豫黔;
YANG Jun,TANG Haibin,HU Yanwen,JIA Yuqian(The Fourth People's Hospital of Guiyang City,Guiyang 550002,China)

摘要(Abstract):

目的:探讨血尿酸(UA)与老年高血压患者颈动脉粥样硬化病变的关系。方法:将90例老年高血压患者按血UA水平分为A组(血UA<300μmol/L)23例,B组(血UA300~399μmol/L)25例,C组(血UA400~499μmol/L)23例,D组(血UA>500μmol/L)19例,20例血UA<300μmol/L的正常老年人为对照(对照组),应用彩色多普勒超声检测其颈动脉内中膜厚度(IMT)、粥样硬化斑块,同时检测血脂、UA及C反应蛋白(CRP)。结果:高血压组的IMT较对照组明显增厚,P<0.01;动脉粥样斑块的检出率明显增高,P<0.05;且血UA高的高血压患者的IMT较血UA正常的高血压者明显增厚(P<0.05)。结论:高UA高血压、及脂质代谢紊乱均是颈动脉粥样硬化的危险因素。
Objective:To study the relationship between carotid artery atherosclerosis and blood uric acid(UA) in the elderly patient's with hypertension.Methods:According to the blood UA levels,90 hypertension patients were divided into four groups:group A(UA<300μmol/L,n=23),group B(300500μmol/L,n=19).Twenty elderly patients(UA<300μmol/L) without disorder of lipid metabolism or heart and cerebral vessele diseases were chosen as control group.The intima-media(IM) thickness and atherosclerotic plaque(AP) in carotid artery were checked with color Doppler ultrasound,and the blood fats,UA and C-response protein(CRP) were tested at the same time.Results:IM was thicker and the detection rate of AP was higher significantly in patients of hypertension groups than those in people of control group(P<0.01,and P<0.05).IM in hypertension patients with high-UA was obviously thicker than that of hypertension patients with normal blood UA levels(P<0.05).Conclusion:High uric acid,high blood pressure and lipid metabolism disorders are risk factors to carotid atherosclerosis.

关键词(KeyWords): 高血压;老年人;尿酸;动脉硬化
hypertension;aged;uric acid;arteriosclerosis

Abstract:

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基金项目(Foundation):

作者(Author): 杨俊;唐海滨;胡艳文;贾豫黔;
YANG Jun,TANG Haibin,HU Yanwen,JIA Yuqian(The Fourth People's Hospital of Guiyang City,Guiyang 550002,China)

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DOI: 10.19367/j.cnki.1000-2707.2008.02.015

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