贵州医科大学学报

1991, (02) 166-167+186

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古尼拟青霉药理作用研究 4.平喘作用及祛痰作用
Study of the Pharmacologic Action of Paecilomyces Gunnii 4 Antiasthmatic and Expectorant Effects

鲍淑娟;李淑芳;钟恒宁;
Bao Shujuan, et al Department of Pharmacology

摘要(Abstract):

本文报道古尼拟青霉(Pacilomyces gunnii)的平喘作用及祛痰作用。通过组胺引起的哮喘动物实验治疗,证明古尼拟青霉5g/kg对哮喘豚鼠具有明显的平喘作用,平喘率达83.3%。本药对脉鼠离体气管平滑肌有轻度松弛作用,并能对抗组胺引起的气管平滑肌的收缩,使收缩高度降低80.2%。同时还有明显的祛痰作用。
A study of the antiasthmatic and expectorant effects of paecilomyces gunnii is reported. The experimental results indicated that paecilomyces gunnii was able to inhibit markedly histamine asthma in guinea-pigs. This antiasthmatic effect was similar to that of aminophylline, but its lasting effect was longer. It had a mild effect of relaxation on the isolated trachial smooth muscle, and an antagonism on the contraction of the trachial smooth muscle which induced by his tamin in guinea-pig. In addition, it had an expectorant effect also.

关键词(KeyWords): 古尼拟青霉;哮喘;豚鼠;小鼠
paecilomyces gunnii;asthma;guinea pigs;mice

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作者(Author): 鲍淑娟;李淑芳;钟恒宁;
Bao Shujuan, et al Department of Pharmacology

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