陆江海,王杉,崔凯荣,邓静,吴侔天,张长久
LU Jiang hai, WANG Shan, CUI Kai rong, DENG Jing, WU Mou tian, ZHANG Chang jiu (Drug Test Center, State Institute for Sports Medicine, Beijing 100029, China)

• 1:国家运动医学研究所兴奋剂检测中心
• 2:国家运动医学研究所兴奋剂检测中心
• 3:国家运动医学研究所兴奋剂检测中心
• 4:国家运动医学研究所兴奋剂检测中心

摘要(Abstract)：

目的 :对莫达芬尼酸和莫达芬尼砜进行核磁共振波谱 (NMR)研究。方法 :采用 1D NMR(1H、13 C NMR、DEPT)和 2D NMR(1H 1HCOSY、HMQC、HMBC)等现代核磁技术检测莫达芬尼酸和莫达尼酸的结构。结果 :归属了莫达芬尼酸和莫达芬尼砜的H、C谱线。结论 :首次报道了莫达芬尼酸和莫达芬尼砜的碳谱数据。
Objective: To study the nuclear magnetic resonance(NMR)spectrum of modafinil acid and modafinil sulfone. Methods: Complete 1H NMR and 13 C NMR assignments of these compounds were carried out using DEPT, HMQC and HMBC techniques. Results: The H and C NMR spectra of the two compounds were sorted. Conclusion: The 13 C NMR data of them are reported for the first time. [

关键词(KeyWords)： 莫达芬尼酸;莫达芬尼砜;磁共振波谱学
modafinil acid; modafinil sulfone; magnetic resonance spectrum analysis,mass

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 陆江海,王杉,崔凯荣,邓静,吴侔天,张长久
LU Jiang hai, WANG Shan, CUI Kai rong, DENG Jing, WU Mou tian, ZHANG Chang jiu (Drug Test Center, State Institute for Sports Medicine, Beijing 100029, China)

Email:

DOI: 10.19367/j.cnki.1000-2707.2004.06.010

参考文献(References)：

• [1]StevenH .Gorman.Determinationofmodafinil,modafinilacidandmodafinilsulfoneinhumanplasmautilizingliquid liquidex tractionandhigh performanceliquidchromatography[J].JChromatography,B 2002,767,269-276.
• [2]ElenaCarceller,ManuelMerlos,MartaGiral.Synthesisandstructure activityrelationshipsof1 acyl4((2 methyl3 pyridyl)cyanomthyl)piperazinesasPAFantagonists[J].JMedChem,1993,36,2984-2997.
• [3]于德泉,杨峻山.分析化学手册第7分册[M].第2版.北京:化学工业出版社,1999.98,556.

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