PHSA-R检测的临床意义Clinical Significance of PHSA-R Detection
程明亮;张金贤;钺定毅;谭柏林;
Chen Mingliang Department of Infetious Disease
摘要(Abstract)：
本文用固相放射免疫法,检测90例各类乙型肝炎病毒感染者血清中聚合人白蛋白受体。结果急性肝炎、慢性活动性肝炎病人之阳性率较乙肝表面抗原携带者、慢性迁延性肝炎为高。随机选择46例阳性者,分别3、6、9个月进行随访表明,PHSA-R与各类肝炎的临床转归有密关系。
PHSA-R were detected (SPRIA) in 90 cases infected with hepatitis B vi- rus. There were 66 PHSA-R positive cases, among them the positivity rate of the patients with acute hepatitis and chronic active hepatitis was higher than that of HBsAg carriers and patients with chronic persistent hepatitis. At random, PHSA-R and liver functions in 46 PHSA-R-positive patients were detected at the 3 rd, 6 th, and 9 th month respectively. Of the patients in whom PHSA-R became negative, the liver functions were normal and the symptoms disappeared, whereas of the patients in whom PHSA-R kept positive, the liver functions were abnormal and the symptoms eontinued. These results suggest that PHSA-R is an important mark using for estimating infectivity, effectiveness of treatment and prognosis of hepatitis.
关键词(KeyWords)：
乙型肝炎;聚合人白蛋白受体;聚合物;白蛋白;受体;人
hepatit-is B; PHSA-R; polymers; albumins; receptors; human
基金项目(Foundation):
作者(Author):
程明亮;张金贤;钺定毅;谭柏林;
Chen Mingliang Department of Infetious Disease
Email:
DOI: 10.19367/j.cnki.1000-2707.1989.02.017
参考文献(References)：
- 1． Machida A, et al. A hepatitis B surface antigen polytide (31) with the receptor for polymerized human as well as chimpantee albumin. Gastroenterology 1983; 85:268．
- 2． 姚光弼,等。HBV白蛋白受体活力与病毒复制的关联。中华传染病杂志1986; 4(3) :125．
- 3． Standring DN, et al. Transcription of the hepatitis B surface antigen gene in cultured murine cells initates within the presurface region. J virol 1984; 50:563．
- 4． LiniunaC et al. Studies on the expression of PHSA on HBV particles. Medicine 1983; 3(4) : 377．
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