贵州医科大学学报

2005, (03) 202-206+210

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中枢型尼古丁胆碱能受体α4外显子5多态性与阿尔茨海默病的关联
Association of Genetic Polymorphisms of Eexon5 of CHRNA4 with Sporadic Alzheimer Disease

齐艳飞,单可人,徐鹰,赵明祥,刘芳,李光荣,张婷,李毅,官志忠,任锡麟
QI Yan-fei 1, SHAN Ke-ren 1, XU Ying 1, ZHAO Ming-xiang 2, LIU Fang 2, LI Guang-rong 2, ZHANG Ting 1, LI Yi 1, GUAN Zhi-zhong 1, REN Xi-lin 1 (1. Molecular Biological Key Laboratory of Guiyang Medical College, Guiyang 550004, China; 2.Department of Neurology, The Affiliated Hospital of Guiyang Medical College, Guiyang 550004, China)

摘要(Abstract):

目的:探讨散发性阿尔茨海默病(SporadicAlzheimerdisease简称SAD)和中枢型尼古丁胆碱能受体α4亚单位(CHRNA4)外显子五基因多态性的关联关系。方法:用聚合酶链式反应-变性梯度凝胶电泳(PCR-DGGE)和DNA测序技术分析23例SAD病人及30例正常人的CHRNA4基因的外显子五序列。结果:在CHR-NA4的外显子五上发现3个多态性位点:G1478A(χ2=0.24,P>0.05);A1374G(χ2=0.24,P>0.05);T1344C(χ2=0.24,P>0.05)。由统计学结果得出该3个多态位点在病例组与对照组之间没有差异。结论:在CHR-NA4外显子五上发现的3个多态性位点与阿尔茨海默病(AD)的发病可能不存在相关关系。
Objective: To investigate the association of genetic polymorphisms of CHRNA4 with sporadic Alzheimer disease. Methods: In 23 sporadic Alzheimer disease (SAD) patients and 30 normal people, exon5 of CHRNA4 was screened with PCR-DGGE technique and sequencing. Results: Three genetic polymrphisms were found in SAD patients and control group:G1487A(χ 2=0.24, P >0.05 );A1374G(χ 2=0.24, P >0.05);T1344C(χ 2=0.24, P >0.05). Conclusions: These three genetic polymorphisms may not be associated with pathogenesis of SAD, since there is no statistical difference between SAD group and control group.

关键词(KeyWords): 阿尔茨海默病;受体,胆碱能;聚合酶链反应;电泳,琼脂凝胶;中枢型尼古丁胆碱能受体α4亚单位
Alzheimer disease; receptors,cholinergic; polymerase chain reaction; electrophoresis, agar gel; nicotinic acetylcholine receptor α4 subunit

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基金项目(Foundation): 国家自然科学基金资助项目(30340080);; 贵州省科学技术厅国际合作资助项目(200211008)

作者(Author): 齐艳飞,单可人,徐鹰,赵明祥,刘芳,李光荣,张婷,李毅,官志忠,任锡麟
QI Yan-fei 1, SHAN Ke-ren 1, XU Ying 1, ZHAO Ming-xiang 2, LIU Fang 2, LI Guang-rong 2, ZHANG Ting 1, LI Yi 1, GUAN Zhi-zhong 1, REN Xi-lin 1 (1. Molecular Biological Key Laboratory of Guiyang Medical College, Guiyang 550004, China; 2.Department of Neurology, The Affiliated Hospital of Guiyang Medical College, Guiyang 550004, China)

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