贵州医科大学学报

2016, v.41;No.190(07) 837-839

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膜联蛋白A2在胃癌患者血清中的表达及意义
The Expression and Value of Serum Annexins A2 in Patients with Gastric Carcinoma

岑美婷;张意钗;黄燕文;臧宁;喻宁芳;钟小雄;
CEN Meiting;ZHANG Yichai;HUANG Yanwen;ZANG Ning;YU Ningfang;ZHONG Xiaoxiong;Department of Laboratory,First People's Hospital of Guangzhou Nansha Hospital;

摘要(Abstract):

目的:检测膜联蛋白A2(ANXA2)在胃癌患者血清中的表达。方法:49例胃癌患者作为胃癌组,55例同期健康体检者作为对照组,采用酶联免疫吸附法检测两组被检者血清中ANXA2和肿瘤标志物CEA、AFPCA19-9及CA24-2水平,采用Pearson法分析胃癌患者血清中ANXA2水平与肿瘤标志物的相关性,采用工作曲线(ROC)分析ANXA2和3种肿瘤标志物对胃癌的诊断价值,探讨ANXA2水平与胃癌淋巴结转移的关系。结果:观察组患者血清中ANXA2、CEA及CA19-9水平均显著高于对照组(P<0.05),观察组患者血清中ANXA2水平与CEA(r=0.905,P<0.05)及CA19-9(r=0.946,P<0.05)水平均呈现显著正相关;以10.11μg/L为截点值,ANXA2诊断胃癌的敏感性为91.84%,特异性为92.73%,优于CEA及CA19-9;伴有淋巴转移胃癌患者血清中ANXA2水平显著高于无淋巴转移患者(t=2.748,P=0.009)。结论:外周血血清中ANXA2水平可作为诊断胃癌的辅助指标。
Objective: To analyze the expression of serum Annexins A2( ANXA2) in patients with gastric carcinoma and its auxiliary diagnostic value. Methods: Clinical data of 49 patients with gastric carcinoma as Group A,55 healthy cases as Group B. ELISA was adopted to test ANXA2,CEA and AFPCA 19-9 and CA24-2 level; adopting Pearson method to analyze correlation between ANXA 2 level and tumor marker; adopting ROC to analyze diagnostic value of ANXA2 and three tumor markers on gastric carcinoma. Results: ANXA2,CEA and CA19-9 level of Group A was obviously higher than these of Group B( P < 0. 05). Correlation analysis showed that,for Group A patients,the levels of ANXA2 had significant positive correlation with CEA( r = 0. 905,P < 0. 05) and CA19-9( r = 0. 946,P< 0. 05). ROC analysis showed that the ANXA2 cut-off point value of 10. 11 ug / L,as used for the diagnosis of gastric carcinoma,provided a sensitivity of 91. 84%,a specificity of 92. 73%,better than these of CEA and CA19-9. Group A patients with lymphatic metastasis had a higher level of ANXA2 than that of patients without lymphatic metastasis( t = 2. 748,P = 0. 009). Conclusion: The level of ANXA2 can be used as an auxiliary diagnosis marker for gastric carcinoma.

关键词(KeyWords): 膜联蛋白A2;胃癌;诊断;肿瘤标记,生物学;淋巴转移
Annexins A2;gastric carcinoma;diagnosis;tumor marker,biological;lymphatic metastasis

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作者(Author): 岑美婷;张意钗;黄燕文;臧宁;喻宁芳;钟小雄;
CEN Meiting;ZHANG Yichai;HUANG Yanwen;ZANG Ning;YU Ningfang;ZHONG Xiaoxiong;Department of Laboratory,First People's Hospital of Guangzhou Nansha Hospital;

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DOI: 10.19367/j.cnki.1000-2707.2016.07.023

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