贵州医科大学学报

1994, (01)

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大鼠肝脏单胺氧化酶及其同工酶活性的增龄变化
The Activity of Monoamine Oxidase and Its Isozymes in Livers of SD Rats with Aging

吴晓黎,张小蕾,唐筑灵
Wu Xiaoli, et al(Department of Biochemistry, Guiyang Medical College)

摘要(Abstract):

用荧光分光光度法检测了3月龄、12月龄和18月龄SD大鼠肝脏单胺氧化酶(MAO)及其同工酶(MAO─A.MAO─B)的活性。结果表明MAO及其两种同工酶的活性均随增龄而升高,成年鼠的酶活性升高尤为显著(P<0.01),升高幅度达幼年鼠67%以上,老年鼠与成年鼠基本持平,只有MAO─A略有升高。
The activity of monoamine oxidase(MAO)and its isozyme A and B in the rat livers of different ages was defected with spectrofluorometry, The results revealed that the activities of MAO,MAO-A and MAO-B of rat livers tended to increase with aging. The mid-aged(12 months) and the old-aged (18months) groups showed a significant rise(P<0.01).This study suggests that the activities of MAO and its isozymes in the rat livers are age-related and may be one the indacators of aging.

关键词(KeyWords): 单胺氧化酶类,同工酶,肝脏,年龄因素
monoamine oxidase; isoenzymes; liver; age factors

Abstract:

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作者(Author): 吴晓黎,张小蕾,唐筑灵
Wu Xiaoli, et al(Department of Biochemistry, Guiyang Medical College)

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DOI: 10.19367/j.cnki.1000-2707.1994.01.013

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