贵州医科大学学报

2003, (03) 202-204

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TNF-α在鼻息肉组织中的表达和意义
The Expression and Significance of Tumor Necrosis Factor-α in Human Nasal Polyps

蒋科会,饶立,叶惠平,林尚泽,陈乾美
JIANG Ke hui, RAO Li, YE Hui ping, LIN Shang ze, CHEN Qian mei (Department of Otorhinolarynglogy, The Affiliated Hospital of Guiyang Medical College, Guiyang 550004, China)

摘要(Abstract):

目的 :探讨肿瘤坏死因子 α(tumornecrosisfactor α ,TNF α)在鼻息肉中的表达和意义。方法 :采用放射免疫分析法研究TNF α在鼻息肉组织匀浆、胎儿下鼻甲组织匀浆和鼻息肉患者的血清、正常成人血清及脐血中的表达及其意义。结果 :鼻息肉组织匀浆、鼻息肉患者的血清、正常成人血清中TNF α平均质量浓度 (μg/L)分别为 1 0 3± 0 14 ,0 79± 0 11,0 79± 0 13,鼻息肉组织匀浆中TNF α的含量高于鼻息肉患者的血清、正常成人血清中的含量 ,差异显著 (P <0 0 1)。结论 :TNF α在鼻息肉中过度表达 ,通过局部炎症微环境的调控 ,在鼻息肉的发生、发展过程中起重要作用
Objective: To study the expression of tumor necrosis factor α(TNF α) in nasal polyps (NP) tissue and their significance. Methods: The expression and significance of TNF α were studied in homogenates of NP, serum samples of NP patients, normal subjects and umbilical cord blood by radioimmunoassay (RIA). Results: The mean values of TNF α(μg/L) in homogenates of NP, serum samples of NP patients and normal subjects were: 1 03±0 14, 0 79±0 11 and 0 79±0 13 respectively. TNF α over expressed in homogenates of NP significantly(P<0 01). Conclusion: The over expression of TNF α in the tissue of NP showing that it plays a predominate role in the genesis and development of NP by means of modulating the local microenviroment of inflammation.

关键词(KeyWords): 鼻息肉;肿瘤坏死因子;放射免疫测定
nasal polyps; tumor necrosis factor; radioimmunoassay

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作者(Author): 蒋科会,饶立,叶惠平,林尚泽,陈乾美
JIANG Ke hui, RAO Li, YE Hui ping, LIN Shang ze, CHEN Qian mei (Department of Otorhinolarynglogy, The Affiliated Hospital of Guiyang Medical College, Guiyang 550004, China)

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