硼、硅、沸石抗氟机理实验研究Experimental Study of Anti-Fluorosis Mechanisms of Boron and Silicon
宋沈超;魏赞道;周琳业;张华;方士杰;
Song Shenchao, et al Department of Preventive Medicine
摘要(Abstract)：
本文通过用硼、硅、沸石对氟中毒大鼠的治疗实验,从氟铝联合作用的角度探讨了它们的抗氟作用和机理。认为其抗氟机理之一可能是影响铝代谢,减轻机体铝负荷,减弱氟铝联合作用,使氟中毒得以改善。
From the viewpoint of the combined effects of fluoride-aluninun(F-Al) anti-fluorosis mechanisms of boron, silicon and zeolite were explored using therapeutic experiments in 86 rats with fluorosis. Borax (400ppm), sodium silicate (150ppm) and zeolite (40000Ppm) were separately added to feed in different experimental group for 13 weeks. We found that in both fluoride group and fluoride-aluminum group the fluoride content of blood and bone did not decrease, though aluminum content of bone, urinary proteins and β_2-microglobulin diminished, and creatinine clearance increased significantly. The results suggested that those reagents might affect aluminum mebolism and reduce aluminum load in the body, weakening the combined effects of F-Al and improving the situations of individuals with fluorosis.
关键词(KeyWords)：
氟化物中毒;铝;硼;硅
fluoride; aluminum; fluorosis; boron; silicon
基金项目(Foundation):
作者(Author):
宋沈超;魏赞道;周琳业;张华;方士杰;
Song Shenchao, et al Department of Preventive Medicine
Email:
DOI: 10.19367/j.cnki.1000-2707.1991.03.011
参考文献(References)：
- 1． Teotia SPS, et al. Treatment of Endemic Fluorosis in Human Beings: An Experimental Study, Fluoride 1976; 9(2) : 98．
- 2． 周琳业,等.复方除氟灵对氟骨症治疗效果的研究.贵州医药 1984;8 (2) :56-59．
- 3． 戴国友,等.氟铝联合作用实验研究.贵阳医学院学报 1990;15 (2) :81-88。
- 4． 徐恩良,等.氟铝联合作用时氟与不同种类铝化合物在代谢中相互作用的差异.贵阳医学院学报 1991;16 (3) :207
- 5． 王子亮,等译.生物体与重金属。北京:中国环境科学出版社,1985;61．
- 6． 周济桂(综述).元素矽生物作用研究的新进展.国外医学地理学分册 1986;3:99-101．
- 7． Carlisle E M, et al.Silicon: An essential element for the chick, Science 1972; 178: 619．
- 8． Kour K, et al. Histological findings in kidneys of mice following sodium fuoride administration. Fluoride 1980; 13 (4) : 163．
- 9． Kessabi M. et al.Experimental acute sodium fluoride poisoning in sheep: renal, hepatic, and metabolic effects, Fluoride 1987; 20 (1) : 41～42．
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