序贯化放疗治疗局部晚期胃癌的近期疗效
熊慧如;董洪敏;王文玲;胡银祥;
摘要(Abstract)：
目的:观察化疗-放疗-化疗序贯治疗局部晚期胃癌的近期疗效和毒副反应。方法:50例局部晚期胃癌患者,分为化-放-化序贯治疗组(观察组)26例和单纯化疗组(对照组)24例,两组均采用DCF或FOLFOX 4方案化疗3~4周期,观察组化疗2周期后行肿瘤累及区域三维适形放疗/调强适形放疗(3DCRT/IMRT)DT 45~50.4Gy/25~28F5~6周,放疗结束再予化疗1~2周期,比较两组疗效、临床症状缓解情况及毒副反应。结果:观察组获完全缓解(CR)1例(3.8%),部分缓解(PR)15例(57.7%),稳定(NC)8例(30.8%),进展(PD)2例(7.7%),总有效率为61.5%,临床症状缓解率92.9%;对照组PR8例(33.3%),NC9例(37.5%),PD7例(29.2%),总有效率为33.3%,临床症状缓解率61.9%;两组治疗有效率、临床症状缓解率比较差异均具有统计学意义,两组毒副反应发生率相近。结论:化-放-化序贯治疗较单纯化疗提高了局部晚期胃癌的治疗有效率,未增加治疗毒副反应。
关键词(KeyWords)：
胃肠肿瘤;放射疗法;化学疗法;序贯治疗
基金项目(Foundation): 贵州省科技厅基金资助项目(E2008-29)
作者(Author):
熊慧如;董洪敏;王文玲;胡银祥;
Email:
DOI: 10.19367/j.cnki.1000-2707.2013.05.021
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