贵州医科大学学报

2018, v.43;No.211(04) 466-469+474

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自体血回输与异体输血对颅脑手术患者部分血清炎症因子及免疫球蛋白水平的影响
Effects of Autologous Blood Transfusion and Allogeneic Blood Transfusion on Serum Inflammatory Factors and Immunoglobulin Levels in Patients with Brain Surgery

屈晶磊;杨远征;
QU Jinglei;YANG Yuanzheng;Department of Blood Components,Blood Center;Department of Critical Care Medicine,First Affiliated Hospital of Hainan Medical College;

摘要(Abstract):

目的:探讨自体血回输与异体输血对颅脑手术患者部分血清炎症因子及免疫球蛋白水平的影响。方法:选取行颅脑手术的患者100例为研究对象,按术中输血方式均分为自体血回输组和异体输血组;分别于术前、术后第1天及第7天采集患者静脉血,采用单向免疫扩散法检测免疫球蛋白Ig G、Ig A及Ig M水平,放射免疫法检测白细胞介素-8(IL-8)、白细胞介素-6(IL-6)及干扰素γ(IFN-γ)水平,采用全自动生化分析仪检测红细胞(RBC)、血红蛋白(Hb)、白细胞(WBC)及血小板(PLT)水平。结果:术后第1天及第7天自体血回输组IL-8、IL-6水平低于异体输血组,IFN-γ水平高于异体输血组,差异有统计学意义(P<0.05);术后第1天及第7天自体血回输组Ig G和Ig A水平明显高于异体输血组、差异有统计学意义(P<0.05),术后两组Ig M水平的差异无统计学意义(P>0.05);术后第1天及第7天自体血回输组RBC及Hb水平明显高于异体输血组,WBC明显低于异体输血组,差异有统计学意义(P<0.05),两组术后PLT水平差异无统计学意义(P>0.05)。结论:自体血回输对颅脑手术患者免疫功能的影响较小,患者术后炎症反应轻。
Objective: To investigate the effects of autologous blood transfusion and allogeneic blood transfusion on serum inflammatory factors and immunoglobulin levels in patients undergoing craniotomy. Methods: From June 2014 to December 2016,the patients who underwent craniotomy were divided into the autologous blood transfusion group and the allogeneic blood transfusion group,with 50 cases in each group. The immunoglobulin,serum inflammatory factors and blood parameters of both groups were detected and analyzed. Results: On the first day and 7~(th) day after operation,the levels of IL-8 and IL-6 were significantly lower and IFN-gamma was significantly higher in the autologous blood transfusion group than those in the allogeneic blood transfusion group( P < 0. 05); The levels of Ig G and Ig A in the autologous blood transfusion group were significantly higher than those in the allogeneic blood transfusion group on the first day and 7~(th) day after the operation,without significant difference between two groups( P < 0. 05); The levels of RBCand Hb in the autologous blood transfusion group were significantly higher than those of the allogeneic blood transfusion group on the first day and 7~(th) day after the operation( P < 0. 05); There was no significant difference in the level of PLT between the two groups on the first day and 7~(th) day after the operation( P > 0. 05). Conclusions: Autologous blood transfusion has less inhibitory effect on immune function and cell carrying capacity of patients with craniotomy. The patients have less inflammatory reaction after operation. It is worthy of clinical application.

关键词(KeyWords): 输血,自体;异体输血;颅脑手术;白细胞介素-8;白细胞介素-6;干扰素γ;免疫球蛋白
blood transfusion,autologous;allogeneic blood transfusion;craniotomy;interluekin 8;interluekin 6;interferon γ;immunoglobulin

Abstract:

Keywords:

基金项目(Foundation): 海南省卫生计生行业科研项目资助(14A210207)

作者(Author): 屈晶磊;杨远征;
QU Jinglei;YANG Yuanzheng;Department of Blood Components,Blood Center;Department of Critical Care Medicine,First Affiliated Hospital of Hainan Medical College;

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DOI: 10.19367/j.cnki.1000-2707.2018.04.020

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