贵州医科大学学报

2016, v.41;No.192(09) 1068-1070

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不同胎龄新生儿血清胱抑素C水平的变化
Analysis of the Changes of Serum Cystatin C Level in Different Gestational Age of Newborn

黄久浪;孙荣荣;陈茂琼;陈晓霞;
HUANG Jiulang;SUN Rongrong;CHEN Maoqiong;CHEN Xiaoxia;Department of Newborn,Affiliated Hospital of Guizhou Medical University;Department of Newborn,People's Hospital of Dongying City;

摘要(Abstract):

目的:探讨不同胎龄新生儿血清胱抑素C(Cys C)水平。方法:434例新生儿,根据胎龄分为早期早产儿(EPI)组、晚期早产儿(LPI)组、足月儿(FTI)组,分别于生后2 h内(开奶前)采静脉血测定血清Cys C、血清肌酐(SCr)及尿素氮(BUN)水平,并进行组间比较。结果:EPI组Cys C水平略高于LPI组,但差异无统计学意义(P>0.05),EPI组及LPI组Cys C水平高于FTI组(P<0.05);3组间SCr及BUN水平比较,差异无统计学意义(P>0.05)。结论:新生儿血清Cys C水平随胎龄增加而降低,早产儿高于足月儿,Cys C可作为反映新生儿肾功能成熟度的指标之一,其敏感度优于SCr、BUN。
Objective: To investigate serum cystatin C level in different gestational age of newborn.Methods: 434 neonates with different gestational age were divided into various groups: early preterm infant group 146 cases,late preterm infant group 138 cases,full term infant group 150 cases. The levels of Serum cystatin C,SCr and BUN were measured within 2 hours after birth( before feeding) and compared. Results: Cys C level of EPI group is slightly higher than LPI group,differences were not statistically significant( P > 0. 05),Cys C level of EPI group and LPI group were higher than FTI group( P < 0. 05); level of Scr and Bun of 3 groups showed no statistical significance( P > 0. 05).Conclusion: The level of Cys decreased with the increase of gestational age,preterm infant was higher than full term infant. Cys C can be used as one of the indicators to reflect the maturity of the renal function in neonates,it is superior to serum SCr and BUN.

关键词(KeyWords): 婴儿,早产;肾功能试验;血清胱抑素C;肾小球滤过率
infant;premature;renal function test;serum cystatin C;glomerular filtration rate

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基金项目(Foundation): 贵州省科技厅科学技术基金[黔科合LG字(2012)052号]

作者(Author): 黄久浪;孙荣荣;陈茂琼;陈晓霞;
HUANG Jiulang;SUN Rongrong;CHEN Maoqiong;CHEN Xiaoxia;Department of Newborn,Affiliated Hospital of Guizhou Medical University;Department of Newborn,People's Hospital of Dongying City;

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