贵州医科大学学报

2004, (06) 484-487+504

[打印本页] [关闭]
本期目录(Current Issue) | 过刊浏览(Past Issue) | 高级检索(Advanced Search)

黏膜相关淋巴组织与结外弥漫大B细胞淋巴瘤临床病理特征和预后比较
A Comparison of Clinicopathological Features and Prognosis of Mucosa Associated Lymphoid Tissue Lymphoma and Extranodal Diffuse Large B-cell Lymphoma

杨文秀,李甘地,周桥,刘卫平
YANG Wen xiu 1, LI Gan di 2* , ZHOU Qiao 2, LIU Wei ping 2 (1. Department of Pathology, Guiyang Medical College, Guiyang 550004, China; 2. Department of Pathology, West China Hospital, Sichuan University, Chengdu 610041,China)

摘要(Abstract):

目的 :比较MALT和结外弥漫大B细胞淋巴瘤的临床病理特征和预后。方法 :94例结外B细胞淋巴瘤 (MALT淋巴瘤 6 2例 ,弥漫大B细胞淋巴瘤 32例 ) ,经HE、免疫组化和PCR复查后 ,收集其临床病理和随访资料 ,并进行统计学分析。结果 :与结外弥漫大B细胞淋巴瘤相比较 ,MALT淋巴瘤发病的中位年龄、临床病理分期、淋巴结转移率和细胞增殖活性均偏低 ;MALT淋巴瘤复发率低于结外DLBCL ,而病人的 5年生存率明显高于结外DLBCL。两种淋巴瘤的ⅠE 期病人的存活情况较ⅠE 期以上的病人好 ;结外DLBCL中 ,有转移者存活状况较无转移者差 ,但MALT淋巴瘤的淋巴结转移与无转移组病例的生存状况无明显差异。结论 :两种淋巴瘤在发病年龄、细胞增殖水平、临床分期、复发等临床病理特征和预后上有明显差异 ;肿瘤分期与两种淋巴瘤的生存状况有关 ,但淋巴结转移仅与结外DLBCL的生存和预后有关 ,而与MALT淋巴瘤无关。
Objective: To compare the clinicopathological features and prognosis of mucosa associated lymphoid tissue (MALT) lymphoma and extranodal diffuse large B cell lymphoma (DLBCL) and to investigate the factors associated with their prognosis. Methods: 94 cases of extranodal B cell lymphomas (including 62 cases of MALT lymphoma and 32 cases of DLBCL) were collected. After recheck with HE and immunohistochemial staining methods and PCR technique, the clinicopathological data and follow up visit data were analyzed statistically. Results: As compared with extranodal DLBCL, the median age, clinicpathological staging, the frequency of lymphatic metastasis and cell proliferation index were low in MALT lymphoma. The survival status of stageⅠ E patient in both MALT lymphoma and extranodal DLBCL groups was better than patients of higher stages. In extranodal DLBCL group, the survival status of patients with lymphatic metastasis was better than that of patients without lymphatic metastasis. While in MALT group, there was not this kind of difference. Conclusions: Statistical differences are noticed between MALT lymphoma and extranodal DLBCL in aspects of median age, cell proliferation, clinicopathological staging, lymphatic metastasis, recurrence and prognosis. The survival status associates with clinical staging in both types of lymphomas. Lymphatic metastasis associates with survival status and prognosis in extranodal DLBCL, not in MALT lymphoma [

关键词(KeyWords): 黏膜相关淋巴组织;淋巴瘤,大细胞,弥漫型;肿瘤转移
mucosa-associated lymphoid tissue; lymphoma, large-cell, diffuse; neoplasm metastasis

Abstract:

Keywords:

基金项目(Foundation): 纽约中华医学基金会基金资助项目(CMB 0 0 - 72 2 )

作者(Author): 杨文秀,李甘地,周桥,刘卫平
YANG Wen xiu 1, LI Gan di 2* , ZHOU Qiao 2, LIU Wei ping 2 (1. Department of Pathology, Guiyang Medical College, Guiyang 550004, China; 2. Department of Pathology, West China Hospital, Sichuan University, Chengdu 610041,China)

Email:

DOI: 10.19367/j.cnki.1000-2707.2004.06.006

文章评论(Comment):

序号(No.) 时间(Time) 反馈人(User) 邮箱(Email) 标题(Title) 内容(Content)
反馈人(User) 邮箱地址(Email)
反馈标题(Title)
反馈内容(Content)
扩展功能
本文信息
服务与反馈
本文关键词相关文章
本文作者相关文章
中国知网
分享