贵州医科大学学报

2002, (03) 196-199

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狼疮性肾炎肾组织中骨调素的研究
A Research on Osteopontin in Kidney Tissue of Patients with Lupus Nephritis

李龙,陈运芬,陈艳,陈永雄,余学清,尹培达,罗建华
LI Long 1, CHEN Yun fen 1, CHEN Yan 2, CHEN Yong xiong 3,YU Xue qing 3, YIN Pei da 3, LUO Jian hua 1 (1.Department of Nephrology, The Affiliated Hospital of Guiyang Medical College, Guiyang 550004, China; 2.Zunyi Xinzhou Hospital, Zunyi 5

摘要(Abstract):

目的 :探讨骨调素 (OPN)在狼疮性肾炎 (LN)肾组织中的表达及意义。方法 :用微波免疫组化双重染色法观察肾组织OPN蛋白的表达 ,用原位杂交检测肾组织OPNmRNA的表达 ,并监测肾功能相关指标。结果 :LN肾小管OPNmRNA及蛋白表达较对照组明显增高。结论 :OPN与LN肾功能损害正相关
Objective:To investigate the expression and clinical significance of osteopontin (OPN) in the kidney tissue of Lupus Nephritis (LN) patients. Methods: The expression of OPN and KP1 (rat antihuman macrophage monoclonal antibody) was detected with microwavebased double labelled immunostaining.The expression of OPN mRNA was detected with in situ hybridization. The relative index of renal function of patients were examined. Results:The OPN Protein and OPN mRNA expressions of LN patients were higher than those of normal group in the tubulointerstitial area. Conclusion: OPN showed a positive correlation with renal lesions in LN.

关键词(KeyWords): 狼疮肾炎;肾小管;免疫组织化学;原位杂交;骨调素
lupus nephritis; kidney tubules; immunohistochemistry; in situ hybridization; osteopontin

Abstract:

Keywords:

基金项目(Foundation): 贵州省卫生厅青年基金资助项目

作者(Author): 李龙,陈运芬,陈艳,陈永雄,余学清,尹培达,罗建华
LI Long 1, CHEN Yun fen 1, CHEN Yan 2, CHEN Yong xiong 3,YU Xue qing 3, YIN Pei da 3, LUO Jian hua 1 (1.Department of Nephrology, The Affiliated Hospital of Guiyang Medical College, Guiyang 550004, China; 2.Zunyi Xinzhou Hospital, Zunyi 5

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DOI: 10.19367/j.cnki.1000-2707.2002.03.003

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