赵丹青;韦艳;沈立明;梁一;
ZHAO Danqing;WEI Yan;SHEN Liming;LIANG Yi;Department of Obstetrics and Gynecology,Affiliated Hospital of Guizhou Medical University;School of Public Health,Guizhou Medical University;College of Life Science and Oceanography,Shenzhen University;

• 1:贵州医科大学附院妇产科
• 2:贵州医科大学公共卫生学院
• 3:深圳大学生命科学与海洋学院

摘要(Abstract)：

目的:探讨妊娠期糖尿病(GDM)的危险因素,为GDM的早期预防提供依据。方法:收集产科门诊妊娠11~16周建卡并完成妊娠24~28周75 g葡萄糖耐量试验(OGTT)的孕妇697例,分为GDM组与非GDM组;问卷调查收集可能影响GDM的一般危险因素[孕妇的年龄、孕前体质指数(BMI)、血压、糖尿病家族史、教育程度、妊娠次数、分娩次数、孕期增重、孕早期空腹血糖值、OGTT、促甲状腺素、血红蛋白、尿酸、白细胞计数、谷丙转氨酶、谷草转氨酶、尿素氮及肌酐],根据资料类型分别采用t检验、χ2检验、秩和检验对各指标进行单因素分析,差异具有显著性的指标进一步作Logistic回归分析影响患GDM的危险因素。结果:单因素分析结果显示,GDM组孕妇的年龄、孕前BMI、血压、孕期增重、糖尿病家族史、妊娠早期空腹血糖、分娩次数、妊娠早期血液尿酸水平、白细胞计数与非GDM组比较,差异有统计学意义(P<0.05);Logistic回归分析结果显示,GDM的危险因素有孕妇年龄、糖尿病家族史、孕前BMI、孕期增重、早期空腹血糖及尿酸。结论:年龄、孕前BMI、糖尿病家族史、空腹血糖、尿酸是GDM的危险因素。
Objective: To investigate risk factors of GDM and provide reference for early prevention for gestational diabetes mellitus( GDM). Method: Data of 697 pregnancy women who registered during pregnancy 11-16 week and then received 75 g oral glucose tolerance test( OGTT). The objects were divided into GDM group and non GDM group. The general risk factors were collected through a questionnaire survey( age,BMI,blood pressure,diabetes history,education background,pregnancy times,delivery times,weight gaining,fasting blood sugar value in early pregnancy,OGTT,TSH,Hb,UA,white blood cell count,GPT,GOT,urea nitrogen and creatinine) According to the data type,t test,C2 test,rank sum test were used to carry out single factor analysis of each index. Further,multiple logistic regression was used to confirm the risk factors of GDM. Result: Single factor analysis showed that there exsisted statistic difference between the GDM group and non-GDM group about age,BMI,blood pressure,weight gaining,diabetes history,fasting blood sugar value in early pregnancy,fasting blood sugar value in early pregnancy,blood uric acid in early pregnancy,white blood cell count,differences were statistically significant( P < 0. 05). Logistic regression analysis showed,the risk factors of GDM were maternal age,diabetes family history,BMI,pregnancy weight gain,early fasting blood glucose and uric acid level. Conclusions: Age,BMI before pregnancy,diabetes family history,fasting blood glucose,uric acid level are the risk factors of GDM.

关键词(KeyWords)： 糖尿病,妊娠;危险因素;血糖;回归分析;诊断;预防
diabetes mellitus,pregnancy;risk factors;blood sugar;regression analysis;diagnosis;prevention

Abstract:

Keywords:

基金项目(Foundation): 贵州省科学技术基金项目[黔科合J字(2015)2014号]

作者(Author): 赵丹青;韦艳;沈立明;梁一;
ZHAO Danqing;WEI Yan;SHEN Liming;LIANG Yi;Department of Obstetrics and Gynecology,Affiliated Hospital of Guizhou Medical University;School of Public Health,Guizhou Medical University;College of Life Science and Oceanography,Shenzhen University;

Email:

DOI: 10.19367/j.cnki.1000-2707.2017.09.010

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