贵州医科大学学报

2020, v.45;No.239(08) 928-932

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BRAF~(V600E)基因突变与甲状腺乳头状癌临床病理特征的相关性
Correlation between BRAF~(V600E) Gene Mutation and Clinicopathological Features of Papillary Thyroid Carcinoma

胡斌;冯江龙;沈丹丹;邓超男;文静;
HU Bin;FENG Jianglong;SHEN DANDan;DENG Chaonan;WEN Jing;Department of Pathology,the Affiliated Hospital of Guizhou Medical University;Department of Ultrasonic Center,the Affiliated Hospital of Guizhou Medical University;

摘要(Abstract):

目的:研究BRAF~(V600E)基因突变与甲状腺乳头状癌(PTC)的临床病理特征的相关性。方法:325例病理诊断为PTC患者作为PTC组,同期50例甲状腺良性病变患者作为对照组,取2组患者手术切除的病灶组织标本提取DNA,采用实时荧光定量PCR法检测2组标本BRAF~(V600E)突变情况,分析BRAF~(V600E)基因突变与PTC组患者临床病理特征的相关性。结果:PTC组患者BRAF~(V600E)基因突变率明显高于对照组,差异有高度统计学意义(P <0.001); PTC组患者BRAF~(V600E)基因突变与甲状腺被膜外侵犯、淋巴结转移及伴有桥本氏甲状腺炎的差异均有统计学意义(P <0.05),BRAF~(V600E)突变与PTC患者预后相关。结论:BRAF~(V600E)基因突变与PTC甲状腺被膜侵犯、淋巴结转移及桥本氏甲状腺炎相关,可作为PTC患者预后的判断依据。
Objective: To investigate the correlation between BRAF~(V600E) gene mutations and clinicopathological features of papillary thyroid carcinoma( PTC). Methods: 325 patients with PTC were collected as PTC group,while 50 patients with benign thyroid lesions as the control group. the focus paraffin tissues of both groups were taken as the specimen,and the DNA in the extracted samples were detected by real-time fluorescence quantitative polymerase chain reaction( PCR) to detect BRAF~(V600E) mutations in the 2 groups and to analyze the correlation between BRAF~(V600E) gene mutations and the clinicopathological features of PTC group. Results: The BRAF~(V600E) gene mutation rate in PTC group was significantly higher than that in the control group( P < 0. 001),and the difference between BRAF~(V600E) gene mutation and extra-membrane invasion, lymph node metastasis and Hashimoto 's thyroiditis in PTC group was statistically significant( P < 0. 05). Conclusion: BRAF~(V600E) gene mutation is associated with thyroid invasion,lymph node metastasis and Hashimoto's thyroiditis,and can be used as a basis for the prognosis of PTC.

关键词(KeyWords): 预后;甲状腺乳头状癌;BRAF~(V600E)基因;淋巴结转移;被膜外侵犯;桥本甲状腺炎
prognosis;papillary thyroid carcinoma(PTC);BRAF~(V600E) gene;lymph node metastasis;extra-membrane invasion;hashimoto's thyroiditis

Abstract:

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基金项目(Foundation): 国家自然科学基金(81760141);; 贵州省自然科学基金资助项目[黔科合基础(2016)1122]

作者(Author): 胡斌;冯江龙;沈丹丹;邓超男;文静;
HU Bin;FENG Jianglong;SHEN DANDan;DENG Chaonan;WEN Jing;Department of Pathology,the Affiliated Hospital of Guizhou Medical University;Department of Ultrasonic Center,the Affiliated Hospital of Guizhou Medical University;

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DOI: 10.19367/j.cnki.2096-8388.2020.08.011

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