贵州医科大学学报

2013, v.38;No.165(06) 632-634

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葛根素对面运动神经元的营养保护作用
Nutrition and Protection Effects of Puerarin on Facial Motor Neuron

苏莉莎;冯俊;杜经纬;方雪;
SU Lisha;FENG Jun;DU Jingwei;FANG Xue;Department of otorhinolaryngology,the Second Clinical Medical Institute of North Sichuan Medical College,Nanchong central hospital;

摘要(Abstract):

目的:探讨葛根素对面运动神经元的营养保护作用。方法:将健康成年雌性去势SD大鼠分为葛根素组和生理盐水组,切断右侧面神经主干复制周围性面瘫模型,术后第3、第7及第15天分别取含神经核的脑组织块,采用HE染色和Tunel法检测右面神经核区面运动神经元数量及形态的变化。结果:术后第15天,葛根素组右侧正常面运动神经元数目较生理盐水组多,差异有统计学意义(P<0.05);生理盐水组的凋亡指数为(29.14±1.35)%,葛根素组的凋亡指数为(24.57±2.23)%,葛根素组凋亡指数比生理盐水组低,差异有统计学意义(P<0.05)。结论:葛根素对面运动神经元具有营养保护作用,可能促进面运动神经元再生。
Objective: To investigate the nutrition and protection effect of puerarin on facial motor neuron. Methods: Dividing female adult ovariectomized SD rats into puerarin group and normal saline group,then we cut the right facial nerve of rats to let it to be peripheral facial paralysis model. During the 3rdday,7thday,15thday after operation,we observed the form and quantity changes of the right facial motor neuron. Results: During the 15thday after operation,apoptotic index of normal saline group was( 29. 14 ± 1. 35) %,and the puerarin group was( 24. 57 ± 2. 23) %,apoptosis rate of puerarin group was lower. Conclusions: Puerarin can protect and enrich facial motor neuron,it may promote regeneration of facial nerve.

关键词(KeyWords): 葛根素;植物雌激素;面神经;面运动神经元;周围性面瘫;凋亡
puerarin;phytoestrogen;facial nerve;facial motor neuron;peripheral acial paralysis;apoptosis

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作者(Author): 苏莉莎;冯俊;杜经纬;方雪;
SU Lisha;FENG Jun;DU Jingwei;FANG Xue;Department of otorhinolaryngology,the Second Clinical Medical Institute of North Sichuan Medical College,Nanchong central hospital;

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