贵州医科大学学报

2015, v.40;No.182(11) 1217-1219

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翼状胬肉切除联合自体角膜缘干细胞移植治疗的效果
Clinical Observation of Pterygium Excision Combined with Corneal Limbus Stem Cell Autografting in Treatment of Pterygium

李英琦;王鲜;
LI Yingqi;WANG Xian;Department of Ophthalmology,Affiliated Hospital of Guizhou Medical University;

摘要(Abstract):

目的:探讨翼状胬肉切除联合自体角膜缘干细胞移植治疗翼状胬肉的临床效果。方法:单眼发病的翼状胬肉患者48例,随机均分为对照组和观察组,对照组采取逆行翼状胬肉剥离术治疗,观察组采取翼状胬肉切除联合自体角膜缘干细胞移植治疗,比较两组患者治疗效果、复发及并发症情况。结果:观察组痊愈率(95.8%)明显高于对照组(75.0%),角膜创面上皮愈合时间明显少于对照组,复发率(4.2%)、结膜充血发生率(16.7%)、创面水肿发生率(8.3%)及异物感发生率(4.2%)均明显低于对照组(25.0%、41.7%、54.2%及29.2%),差异均有统计学意义(P<0.05)。结论:翼状胬肉切除联合自体角膜缘干细胞移植治疗翼状胬肉的效果优于逆行翼状胬肉剥离术。
Objective: To investigate the efficacy of pterygium excision combined with corneal limbus stem cell autografting in treatment of pterygium. Methods: Forty-eight patients with unilateral pterygium were chosen and randomly divided into observation group and control group. Patients in control group received retrograde decollement surgery,while patients in observation group received pterygium excision combined with corneal limbus stem cell autografting. The treatment effect,recurrence and complications were compared between patients in two groups. Results: The cure rate( 95. 8%) of the observation group was significantly higher than that of control group( 75. 0%); Corneal epithelial wound healing time of observation group was significantly shorter than that of control group; The recurrent rate( 4. 2%),the incidence of conjunctival hyperemia( 16. 7%),the incidence of wound edema( 8. 3%),and the incidence of foreign body sensation( 4. 2%) of observation group were significantly lower than their counterparts of control group( 25. 0%,41. 7%,54. 2% and 29. 2%,respectively).All differences between observation and control group showed statistical significance( P < 0. 05). Conclusions: Pterygium excision combined with corneal limbus stem cell autografting is a better surgical technique in treating pterygium than the retrograde decollement surgery.

关键词(KeyWords): 角膜缘干细胞;移植,自体;逆行翼状胬肉剥离术;翼状胬肉
corneal limbus stem cell;graft,auto;retrograde decollement;pterygium

Abstract:

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作者(Author): 李英琦;王鲜;
LI Yingqi;WANG Xian;Department of Ophthalmology,Affiliated Hospital of Guizhou Medical University;

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DOI: 10.19367/j.cnki.1000-2707.2015.11.022

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