贵州医科大学学报

2016, v.41;No.190(07) 865-868

[打印本页] [关闭]
本期目录(Current Issue) | 过刊浏览(Past Issue) | 高级检索(Advanced Search)

维生素E预防早产儿贫血的效果
Clinical Effects of Vitamin E in the Prevention of Anemia

马裕斌;曾虹;李建东;陈锐佳;
MA Yubin;ZENG Hong;LI Jiandong;CHENG Ruijia;Department of Neonatology,the Affiliated Chaozhou Central Hospital of Southern Medical University;

摘要(Abstract):

目的:探讨维生素E(VE)预防早产儿贫血的最佳剂量和临床疗效。方法:84例早产儿均分为大剂量VE组[20 mg/(kg·d)]、小剂量VE组[5 mg/(kg·d)]及对照组,对照组给予常规奶粉、营养支持治疗,大、小剂量VE组在对照组治疗基础上给予相应剂量VE口服,连续治疗4周,比较3组早产儿治疗前及治疗第1、第2、第3及第4周时血红蛋白浓度(Hb)、红细胞计数(RBC)、红细胞压积(Hct)、网织红细胞计数(Ret)、血清铁(SF)含量及总铁结合力(TIBC),比较治疗前后早产儿血清中的VE浓度;记录3组早产儿治疗过程中输血率及不良反应。结果:3组早产儿治疗前Hb、RBC、Hct、Ret、SF含量及TIBC比较,差异无统计学意义(P>0.05);治疗第2、第3及第4周时VE组Hb、RBC、Hct、Ret高于对照组,SF含量及TIBC低于对照组(P<0.05),治疗第1、第2、第3及第4周时大剂量VE组Hb、RBC、Hct、Ret、SF含量及TIBC与小剂量VE组比较,差异无统计学意义(P>0.05);治疗前,3组早产儿血清VE浓度比较,差异无统计学意义(P>0.05);治疗后,血清VE水平表现为大剂量组>小剂量组>对照组,差异有统计学意义(P<0.05);大、小剂量VE组早产儿输血率显著低于对照组(P<0.05)。结论:补充小剂量VE[5 mg/(kg·d)]可有效预防早产儿贫血,降低早产儿贫血发生率。
Objective: To explore the best dosage and clinical effect of VE in preventing anemia in preterm infants. Methods: 84 cases of preterm children were randomly divided into low-dose group( 5 mg /kg· d),high dose group( 20 mg /kg· d) and control group. Control group was given conventional milk powder,nutrition support treatment. Based on the control group treatment,high dose group and low dose group received continuous treatment of corresponding dose of oral VE for 4 weeks.Hemoglobin concentration( HB),red blood cell count( RBC),red blood cell count( HCT),serum iron( RET) and total iron binding capacity( TIBC) were compared between the 3 groups before treatment and 1 week,2 weeks,3 weeks and 4 weeks after treatment. VE concentration in serum of preterm infants was compared between before treatment and after treatment. Blood transfusion rate and adverse reactions were recorded in the 3 groups of premature infants. Results: Before treatment,there were no statistically significant differences in content of Hb,RBC,HCT,RET,SF,and TIBC between the three groups( P > 0. 05). In VE treatment group,the content of Hb,RBC,HCT,RET and SF was significantly higher than their counterparts in control group at 2~(th) week after treatment,3~(th)week after treatment and 4th week after treatment,and the content of SF and the TIBC were significantly lower than those of control group( P < 0. 05). There were no statistically significant differences in content of Hb,RBC,HCT,RET,SF,and TIBC between the high dose VE group and low dose VE groupat 2~(th)week after treatment,3~(th)week after treatment and 4th week after treatment( P > 0. 05). Before treatment,there was no significant difference in the serum VE concentrations between the 3 groups( P> 0. 05). After treatment,the level of serum VE was significantly higher than that of control group,the difference was statistically significant( P < 0. 05). The transfusion rate of preterm infants in VE group was significantly lower than that in control group( P < 0. 05). Conclusion: The supplementation of low dose VE( 5 mg / kg·d) can effectively prevent premature infant anemia and reduce the incidence of anemia in premature infants.

关键词(KeyWords): 维生素E;婴儿,早产;贫血;血液学
vitamin E;infant,premature;anemia;hematology

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 马裕斌;曾虹;李建东;陈锐佳;
MA Yubin;ZENG Hong;LI Jiandong;CHENG Ruijia;Department of Neonatology,the Affiliated Chaozhou Central Hospital of Southern Medical University;

Email:

DOI: 10.19367/j.cnki.1000-2707.2016.07.031

参考文献(References):

文章评论(Comment):

序号(No.) 时间(Time) 反馈人(User) 邮箱(Email) 标题(Title) 内容(Content)
反馈人(User) 邮箱地址(Email)
反馈标题(Title)
反馈内容(Content)
扩展功能
本文信息
服务与反馈
本文关键词相关文章
本文作者相关文章
中国知网
分享