贵州医科大学学报

1994, (02)

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免疫放射法新生儿TSH测定在碘缺乏监测中的特异性
Exploration of the Specificity of Neonate TSH-IRMA Measurement for monitoring IDD

时立新,马启玲,时钟孚,张家秀,杨里福
Shi Lixin; et al (Endocrine Unit, Affiliated Hospital of Guiyang Medical College)

摘要(Abstract):

通过分析比较贵州省加碘地区麻江县和非加碘城市上海的新生儿TSH值分布,探讨免疫放射法(IRMA)纸片新生儿TSH值测定在碘缺乏人群监测应用中的特异性。结果显示:1.麻江县新生儿TSH值<5mIU/L者占65.7%,上海市新生儿占73.4%,两者比较无显著性差异(P>0.05);2.麻江县孕妇尿碘值>100μg/L者占55.8%,上海市孕妇占27.4%,两者比较有极显著性差异(P<0.01)。结果表明,IRMA纸片新生儿TSH测定在碘缺乏的监测中特异性似不强,可能会受到除碘缺乏以外的其它致甲状腺肿物质的影响
The neonatal TSH distribution of iodine supplement county of Majiang in Guizhou province and non iodine supplement city of Shanghai were compared in the present study. The study aims to explore the specificity of neonatal TSH measurement using immunoradiometric Assay(TSHIRMA ) method for monitoring iodine deficiency disorders(IDD). The results showed :(1) the percentage of subjects with TSH values <5 mIU/L in neonate group of Majiang was 65.7%, in neonate group of shanghai it was 73.4%(P>0.05);(2)The percentage of subjects with urinary iodine values>100 u1g/L in pregnant women group of Majiang was 55.8%, in pregnant women group of Shanghai it was 27.4%(P<0.01). The results indicate that the specificity of neonate TSH-IRMA measurement is not strong for monitoring IDD and might be influenced by other goitrogens except iodine.

关键词(KeyWords): 促甲状腺素,碘,缺乏病,免疫放射法
TSH; iodine; deficiency diseases; IRMA

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作者(Author): 时立新,马启玲,时钟孚,张家秀,杨里福
Shi Lixin; et al (Endocrine Unit, Affiliated Hospital of Guiyang Medical College)

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DOI: 10.19367/j.cnki.1000-2707.1994.02.012

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