贵州医科大学学报

2017, v.42;No.201(06) 741-744

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利拉鲁肽与胰岛素治疗2型糖尿病的疗效比较
Comparison of Curative Efficacy of Liraglutide and Insulin in the Treatment of Type 2 Diabetes

陈彦平;
CHEN Yanping;Department of Internal Medicine,Vallely Hospital of Traditional Chinese Medicine;

摘要(Abstract):

目的:比较利拉鲁肽与胰岛素治疗2型糖尿病患者的临床疗效。方法:选择2型糖尿病患者80例,随机分为观察组和对照组,观察组患者采用二甲双胍联合利拉鲁肽治疗,对照组患者接受二甲双胍及胰岛素治疗,均治疗3个月;比较两组治疗前后空腹血糖(FPG)、餐后2 h血糖(2h PG)、糖化血红蛋白(Hb Alc)、体重、体重指数(BMI)及腰围变化,比较治疗前后观察组空腹胰岛素(Fins)、胰岛素抵抗指数(HOMA-IR)及胰岛B细胞功能指数(HOMA-β),同时观察两组的不良反应发生率。结果:在治疗结束后,两组患者FPG、2h PG、Hb Alc水平、体重、体重指数(BMI)及腰围均低于治疗前(P<0.05),且观察组低于对照组(P<0.05);观察组患者在治疗后的Fins、HOMA-IR水平显著下降,HOMA-β水平明显提高,不良反应发生率明显低于对照组,差异均有统计学意义(P<0.05)。结论:利拉鲁肽治疗2型糖尿病患者的临床疗效较好,相对安全性较高。
Objective: To compare the curative effect of liraglutide and insulin in treatment of patients with type 2 diabetes mellitus. Methods: Eighty cases of patients with type 2 diabetes were randomly divided into observation group and control group. Patients in observation group were treated with metformin combined with liraglutide for 3 months,patients in the control group received the treatment of insulin combined with metformin for 3 months. Fasting blood glucose( FPG),postprandial 2 h blood glucose( 2h PG),glycosylated hemoglobin( Hb Alc),weight,body mass index( BMI) and waist circumference were compared between the two groups before and after treatment. The fasting insulin( Fins),insulin resistance index( HOMA-IR) and the B cell function index( HOMA-beta) of the observation group were compared before and after treatment,and the incidence of adverse reactions in the two groups was observed. Results: At the end of treatment,FPG,2h PG,Hb Alc level,body weight,body mass index( BMI) and waist circumference of the two groups were lower than those before treatment( P < 0. 05),and after treatment,these indexes in observation group were lower than control group( P < 0. 05); after treatment,Fins and HOMA-IR of the patients in the observation group decreased significantly,HOMA-levels increased significantly,the incidence of adverse reactions in observation group was significantly lower than the control group,the differences were statistically significant( P < 0. 05). Conclusion: The curative efficacy of liraglutide the clinical efficacy of patientsn in the treatment of type 2 diabetes mellitus is good,and relatively safe.

关键词(KeyWords): 利拉鲁肽;胰岛素;血糖;糖化血红蛋白;2型糖尿病;疗效;安全性
liraglutide;insulin;blood glucose;glycosylated hemoglobin;type 2 diabetes;curative efficacy;safety

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 陈彦平;
CHEN Yanping;Department of Internal Medicine,Vallely Hospital of Traditional Chinese Medicine;

Email:

DOI: 10.19367/j.cnki.1000-2707.2017.06.026

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