贵州医科大学学报

2019, v.44;No.228(09) 1105-1108+1112

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2型糖尿病患者血小板参数及血小板表面相关膜糖蛋白和线粒体膜电位表达的临床意义
Clinical Significance of Platelet-related Parameter, Platelet Surface Associated Membrane Glycoprotein and Mitochondrial Membrane Potential in Type 2 Diabetes

余司文;武强;王艳华;贺乐奇;沈芳;
YU Siwen;WU Qiang;WANG Yanhua;HE Leqi;SHEN Fang;Clinical Laboratory, the Fifth People's Hospital of Shanghai Affiliated to Fudan University;

摘要(Abstract):

目的:探讨2型糖尿病(T2DM)患者血小板参数、血小板聚集功能(PAgT)、血小板表面相关膜糖蛋白(CD41b、CD61和CD62P)及线粒体膜电位(Δψm)表达的临床意义。方法:选取75例T2DM患者和50例健康对照者,取清晨空腹静脉血,检测血小板计数(PLT)、血小板平均体积(MPV)、血小板压积(PCT)、血小板分布宽度(PDW)、PAgT、CD41b、 CD61、CD62P及Δψm的变化。结果:与对照组比较,T2DM患者MPV、PDW及PAgT水平均升高(P<0.05);Δψm表达降低(P<0.05); CD41b、CD62P表达升高(P<0.05)。结论:T2DM患者部分血小板相关参数发生变化,这些参数的变化可能是糖尿病患者微血管病变的早期指标。
Objective: To probe into the clinical significance of platelet parameters, platelet aggregation function(PAgT), platelet surface associated membrane glycoprotein(CD41b、CD61 and CD62P) and mitochondrial, membrane potential(ΔΨm) expression in patients with type 2 diabetes mellitus(T2DM). Methods: 75 cases with T2DM and 50 healthy people were involved, mensuration of platelet parameters(PLT, MPV, PCT,PDW, PAgT, CD41b, CD61, CD62P, ΔΨm) expressions were respectively given to 75 patients with T2DM and 50 healthy controls to observe the difference between the two groups. Results: Compared with the control group, the diabetic group showed an increase in PDW,MPV and PAgT(P<0.05); ΔΨm expression decreased(P<0.05); the CD41b and CD62P expression rose up(P<0.05). Conclusion: MPV, PDW, PAgT, CD41b and CD62P expression level increased significantly and ΔΨm expression is reduced in patients with T2DM. These parameter changes can be used as early indicators to assess the risk of vascular complications for T2DM.

关键词(KeyWords): 糖尿病;血小板;血小板膜糖蛋白类;血小板聚集率;血小板线粒体膜电位;微血管病变
diabetes;platelet;platelet membrane glycoprotein;platelet aggregation rate;platelet mitochondrial membrane potential;microvascular lesion

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基金项目(Foundation): 闵行区卫生和计划生育委员会项目(2016MW06)

作者(Author): 余司文;武强;王艳华;贺乐奇;沈芳;
YU Siwen;WU Qiang;WANG Yanhua;HE Leqi;SHEN Fang;Clinical Laboratory, the Fifth People's Hospital of Shanghai Affiliated to Fudan University;

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DOI: 10.19367/j.cnki.1000-2707.2019.09.024

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