贵州医科大学学报

2018, v.43;No.211(04) 406-411

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心脉通胶囊对麻醉Beagle犬血流动力学的影响
Effects of Xinmaitong Capsule on Hemodynamics in Anaesthetized Beagle Dogs in vivo

李谦;付凌云;潘迪;徐旖旎;陶玲;沈祥春;杨青波;
LI Qian;FU Lingyun;PAN Di;XU Yini;TAO Ling;SHEN Xiangchun;YANG Qingbo;Laboratory of Natural Medicine Resource Utilization,School of Pharmacy,Guizhou Medical Univesity;Key Laboratory of Natural Medicine Pharmacology and Pharmaceutical Properties of Institue of Higher Learning in Guizhou,Guizhou Medical Univesity;Center of National Miao Medicine Engineering Technology,Guizhou Yibai Pharmaceutical Co.Ltd.;

摘要(Abstract):

目的:探讨心脉通胶囊(XMT)对麻醉Beagle犬部分血流动力学指标的影响。方法:30只Beagle犬随机分为5组,XMT低剂量(0.2 g/kg)、中剂量组(0.4 g/kg)、高剂量组(0.8 g/kg),以山绿茶降压胶囊(0.16 g/kg)为阳性对照组,以生理盐水组为阴性对照;各组动物手术分离十二指肠给药,比较给药前、给药30、45、60、90、120、150及180 min时Beagle犬的收缩压(SAP)、平均动脉压(MAP)、舒张压(DAP)、心率(HR)、左室内压(LVSP)、左室作功指数(LVWI)、总耗氧指数(TTI)及总外周血管阻力(TPVR)。结果:与生理盐水组相比,XMT高、中剂量组部分时间点SAP、MAP、LVSP、TPVR显著降低(P<0.05,或P<0.01),部分时间点LVWI、TTI水平显著减少(P<0.05);高剂量组部分时间点DAP显著降低(P<0.05);但各组Beagle犬的HR比较,差异无统计学意义(P>0.05)。结论:XMT对麻醉Beagle犬降低血压的同时,并不减少心脏供血,其机制可能与减少后负荷,扩张外周血管有关。
Objective: To investigate the effects of Xinmaitong( XMT) capsule on hemodynamics in anesthetized Beagle dogs. Methods: 30 Anesthetized dogs were divided into five groups as follows:negative control group treated with normal saline,positive control group treated with 0. 16 g/kg Shanlvcha Jiangya capsule,and XMT low dose group( 0. 2 g/kg),XMT medium dose group( 0. 4 g/kg),XMT high dose group( 0. 8 g/kg),respectively. All dogs were adminstrated duodenal surgery and treatment. Observing SAP,MAP,DAP,HR,LVSP,LVWI,TTI and TPVR while treated at 30,45,60,90,120,150 and 180 min. Results: Comparing with saline group,certain time points in XMT hight and medium dose group showed significant lowering in SAP,MAP,LVSP,and TPVR indexes( P < 0. 05,or P < 0. 01); certain time points showed obvious reduce in LVWI and TTI levles( P <0. 05); comparison of HR of all groups shoed no statistical significance( P > 0. 05). Conclusion: Xinmaitong capsule has a significant effect on reducing blood pressure,while maintaining heart blood supply,which is related to the reducing afterload and the expansion of the peripheral blood vessels.

关键词(KeyWords): 血流动力学;血压;心脉通胶囊;麻醉;犬,Beagle
hemodynamics;blood pressure;Xinmaitong capsule;anesthesia;Beagle dogs

Abstract:

Keywords:

基金项目(Foundation): 贵州省科技计划项目[黔科合支撑(2017)2834];; 贵州省高等教育科技创新团队项目[黔教合人才团队字(2014)31];; 贵州省科技创新团队项目[黔科合人才团队(2015)4025号];; 贵州省高层次创新型人才百层次人才项目[黔科合人才(2015)4029]

作者(Author): 李谦;付凌云;潘迪;徐旖旎;陶玲;沈祥春;杨青波;
LI Qian;FU Lingyun;PAN Di;XU Yini;TAO Ling;SHEN Xiangchun;YANG Qingbo;Laboratory of Natural Medicine Resource Utilization,School of Pharmacy,Guizhou Medical Univesity;Key Laboratory of Natural Medicine Pharmacology and Pharmaceutical Properties of Institue of Higher Learning in Guizhou,Guizhou Medical Univesity;Center of National Miao Medicine Engineering Technology,Guizhou Yibai Pharmaceutical Co.Ltd.;

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DOI: 10.19367/j.cnki.1000-2707.2018.04.007

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