李谦;付凌云;潘迪;徐旖旎;陶玲;沈祥春;杨青波;
LI Qian;FU Lingyun;PAN Di;XU Yini;TAO Ling;SHEN Xiangchun;YANG Qingbo;Laboratory of Natural Medicine Resource Utilization,School of Pharmacy,Guizhou Medical Univesity;Key Laboratory of Natural Medicine Pharmacology and Pharmaceutical Properties of Institue of Higher Learning in Guizhou,Guizhou Medical Univesity;Center of National Miao Medicine Engineering Technology,Guizhou Yibai Pharmaceutical Co.Ltd.;

• 1:贵州医科大学药学院天然药物资源优效利用重点实验室
• 2:贵州医科大学药学院贵州省普通高等学校天然药物药理与成药性评价特色重点实验室
• 3:国家苗药工程技术中心贵州益佰制药股份有限公司

摘要(Abstract)：

目的:探讨心脉通胶囊(XMT)对麻醉Beagle犬部分血流动力学指标的影响。方法:30只Beagle犬随机分为5组,XMT低剂量(0.2 g/kg)、中剂量组(0.4 g/kg)、高剂量组(0.8 g/kg),以山绿茶降压胶囊(0.16 g/kg)为阳性对照组,以生理盐水组为阴性对照;各组动物手术分离十二指肠给药,比较给药前、给药30、45、60、90、120、150及180 min时Beagle犬的收缩压(SAP)、平均动脉压(MAP)、舒张压(DAP)、心率(HR)、左室内压(LVSP)、左室作功指数(LVWI)、总耗氧指数(TTI)及总外周血管阻力(TPVR)。结果:与生理盐水组相比,XMT高、中剂量组部分时间点SAP、MAP、LVSP、TPVR显著降低(P<0.05,或P<0.01),部分时间点LVWI、TTI水平显著减少(P<0.05);高剂量组部分时间点DAP显著降低(P<0.05);但各组Beagle犬的HR比较,差异无统计学意义(P>0.05)。结论:XMT对麻醉Beagle犬降低血压的同时,并不减少心脏供血,其机制可能与减少后负荷,扩张外周血管有关。
Objective: To investigate the effects of Xinmaitong( XMT) capsule on hemodynamics in anesthetized Beagle dogs. Methods: 30 Anesthetized dogs were divided into five groups as follows:negative control group treated with normal saline,positive control group treated with 0. 16 g/kg Shanlvcha Jiangya capsule,and XMT low dose group( 0. 2 g/kg),XMT medium dose group( 0. 4 g/kg),XMT high dose group( 0. 8 g/kg),respectively. All dogs were adminstrated duodenal surgery and treatment. Observing SAP,MAP,DAP,HR,LVSP,LVWI,TTI and TPVR while treated at 30,45,60,90,120,150 and 180 min. Results: Comparing with saline group,certain time points in XMT hight and medium dose group showed significant lowering in SAP,MAP,LVSP,and TPVR indexes( P < 0. 05,or P < 0. 01); certain time points showed obvious reduce in LVWI and TTI levles( P <0. 05); comparison of HR of all groups shoed no statistical significance( P > 0. 05). Conclusion: Xinmaitong capsule has a significant effect on reducing blood pressure,while maintaining heart blood supply,which is related to the reducing afterload and the expansion of the peripheral blood vessels.

关键词(KeyWords)： 血流动力学;血压;心脉通胶囊;麻醉;犬,Beagle
hemodynamics;blood pressure;Xinmaitong capsule;anesthesia;Beagle dogs

Abstract:

Keywords:

基金项目(Foundation): 贵州省科技计划项目[黔科合支撑(2017)2834];; 贵州省高等教育科技创新团队项目[黔教合人才团队字(2014)31];; 贵州省科技创新团队项目[黔科合人才团队(2015)4025号];; 贵州省高层次创新型人才百层次人才项目[黔科合人才(2015)4029]

作者(Author): 李谦;付凌云;潘迪;徐旖旎;陶玲;沈祥春;杨青波;
LI Qian;FU Lingyun;PAN Di;XU Yini;TAO Ling;SHEN Xiangchun;YANG Qingbo;Laboratory of Natural Medicine Resource Utilization,School of Pharmacy,Guizhou Medical Univesity;Key Laboratory of Natural Medicine Pharmacology and Pharmaceutical Properties of Institue of Higher Learning in Guizhou,Guizhou Medical Univesity;Center of National Miao Medicine Engineering Technology,Guizhou Yibai Pharmaceutical Co.Ltd.;

Email:

DOI: 10.19367/j.cnki.1000-2707.2018.04.007

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