贵州医科大学学报

1999, (03) 227-228

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单纯疱疹病毒感染与冠心病发作相关性的探讨
The Study on the Correlativity of Herpes Simplex Virus Infection with the Bout of Coronary Atherosclerotic Heart Disease

潘积慧,左丽
Pan Jihui,et al Department of Internal Medicine,The Second Affitiated Hospital of Guiyang Medical College

摘要(Abstract):

研究单纯疱疹病毒 (HSV)感染与冠心病发作的相关性。分别采集 30例冠心病住院病人发作期和缓解期血清 ,并设正常老年组对照 ,常规间接ELISA法检测各组血清中抗HSV特异特IgM、IgG及其水平。结果显示 ,冠心病发作组、缓解组和正常老年组血清中抗HSVIgM阳性率分别为 4 0 0 % ,13 3%和 10 0 % ,阳性血清平均效价分别为 1∶850 ,1∶30 0 ,1∶30 0。经t检验 ,冠心病发作组抗HSVIgM阳性率及平均效价均明显高于其余两组 (P <0 0 1)。冠心病发作组、缓解组和正常老年组血清抗HSVIgG阳性率分别为 73 33% ,80 0 0 %和 70 0 0 % ,阳性血清平均效价分别为 1∶2 50 ,1∶80 0和 1∶2 50 ,经t检验 ,各组间抗HSVIgG阳性率无明显差异 (P >0 0 5) ,但缓解组抗HSVIgG平均效价明显高于发作组与正常老年组 (P <0 0 1)。结果提示 ,冠心病发作可能与HSV急性感染有一定关系。
In order to study the correlativity of herpes simplex virus (HSV) infection with the bout of coronary athero-sclerotic heart disease(CAHD),60 serum samples from 30 patients with CAHD in episodical and relaxant periods,30 serum samples of nomal elders were collected,respectively.Contents of the specific anti-HSV IgG,IgM class antibody were obtermined by ELISA.The results showed that the positive rates of the specific IgM were 40 0%,13 3% and 10 0%,the levels of the averagel titer of positive serum samples were 1∶850,1∶300 and 1∶300 in the episodical,relaxant and normal groups,respectively.The standard of the positive rate and avarage titer of the specific IgM of episodical patients with CAHD were obviously higher than those of the others by statistic way.The positive rates of the specifical IgG were 73 33%,80 00% and 70 00%,the levels of the IgG average titer of the positive serum samples were 1∶250,1∶800 and 1∶250 in the episodical,relaxant and normal groups,respectively.The IgG positive rate of anti-HSV was little different among these groups by statistics way.But the level of specifical IgG average titer in the relaxant patients with CAHD was obvirusly higher than those in other groups.The results suggested that there might be correlativity between HSV acute and activatied latent infection with the bout of CAHD.

关键词(KeyWords): 单纯疱疹病毒;冠状动脉粥样硬化性心脏病;免疫球蛋白M类;免疫球蛋白G类;酶联免疫吸附试验
herpes simplex virus;coronary atherosclerotic heart disease;IgG; IgM; enzyme-linked immunosorbent assay

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作者(Author): 潘积慧,左丽
Pan Jihui,et al Department of Internal Medicine,The Second Affitiated Hospital of Guiyang Medical College

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