贵州医科大学学报

2002, (06) 497-499

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β-catenin和APC蛋白在甲状腺肿瘤中的表达及意义
Expression of β-catenin and APC Protein in Thyroid Neoplasm and Its Implication

董泾青,沈祖楹,于扬,赵代伟,刘茂玲
DONG Jing qing, SHEN Zu ying, YU Yang , ZHAO Dai wei, LIU Mao ling (Department of General Surgery, The Affiliated Hospital of Guiyang Medical College, Guiyang 550004, China)

摘要(Abstract):

目的 :探讨甲状腺正常组织、甲状腺腺瘤和甲状腺癌中 β catenin和APC蛋白的表达特征及其意义。 方法 :采用S -P(S -ABC)免疫组化法检测 4 0例甲状腺腺瘤旁正常组织、4 0例甲状腺腺瘤和 39例甲状腺癌手术标本 β catenin和APC蛋白的表达。 结果 :β catenin在 4 0例正常甲状腺组织中均为正常阳性表达 ,在 4 0例甲状腺腺瘤中异常表达率为 5 7.5 % (2 3/ 4 0 ) ,在 39例甲状腺癌中异常表达率为 10 0 % (39/ 39)。APC蛋白在正常甲状腺组织、甲状腺腺瘤和甲状腺癌中正常阳性表达率分别为 10 0 % (40 / 4 0 )、97.5 % (39/ 4 0 )和 97.4 % (38/ 39)。结论 :β catenin在正常甲状腺组织中均为正常阳性表达 ,在甲状腺腺瘤和甲状腺癌中呈异常表达 ,甲状腺癌异常表达率高于甲状腺腺瘤 ,两者异常表达率有显著差别 (P <0 .0 0 5 )。APC蛋白表达在甲状腺正常组织、甲状腺腺瘤和甲状腺癌中未发现显著差别 (P >0 .0 5 )。
Objective: To investigate the expression of β catenin and protein APC in thyroid normal tissue, thyroid adenoma,thyroid carcinoma, and their implication. Methods: Immunohistochemical staining with S-P(S-ABC) method was conducted to determine the expression of β catenin and protein APC in thyroid normal tissue around thyroid adenoma (40 cases), thyroid adenoma (40 cases) and thyroid carcinoma (39 cases). Results: β catenin was normally positive in all 40 cases of normal thyroid tissue. Its abnormal expression was found in 23/40(57 5%) of adenoma and 39/39(100%) of carcinoma. Normal positive expression of APC protein was found in 40/40(100%) of normal tissue, 39/40(97.5%) of adenoma and 38/39(97.4%) of carcinoma. Conclusion: Expression of β catenin was uniformly positive in thyroid normal tissue. Its abnormal expression was found in thyroid adenoma and thyroid carcinoma. The rate of abnormal expression of β catenin in thyroid carcinoma is higher than that in thyroid adenoma. There was a significant difference of abnormal expression rate of β catenin between thyroid adenoma and thyroid carcinoma (P<0.005). Obvious difference of expression of APC protein was not detected among thyroid normal tissue, thyroid adenoma and thyroid carcinoma (P>0.05).

关键词(KeyWords): 甲状腺肿瘤;基因表达;免疫组织化学;甲状腺
thyroid neoplasms; gene expression; immunohistochemistry; thyroid gland

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作者(Author): 董泾青,沈祖楹,于扬,赵代伟,刘茂玲
DONG Jing qing, SHEN Zu ying, YU Yang , ZHAO Dai wei, LIU Mao ling (Department of General Surgery, The Affiliated Hospital of Guiyang Medical College, Guiyang 550004, China)

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