贵州医科大学学报

1999, (03) 221-223

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喉鳞癌组织p53表达与细胞增殖活性的关系
Correlation between p53 Protein Exprssion and Tumor-Cell Proliferation in Carcinoma of Larynx

周光耀,林代诚,梁传余,张贤良,文定厚,刘亚峰
Zhou Guangyao,et al Department of Otolaryngology,First Hospital,West China University of Medical Sciences

摘要(Abstract):

为探讨喉上皮癌前病变及癌组织 p53蛋白的表达与细胞增殖活性的关系 ,应用免疫组化技术对 11例喉上皮单纯性增生 (SHE)、32例非典型性增生 (AHE)及 4 2例喉鳞癌 (LSCC)进行研究。结果显示 :31 2 5%及 52 38%的AHE及LSCCp53蛋白阳性表达 ;p53蛋白阳性的AHE及LSCC ,其细胞增殖活性均较阴性者高 (P <0 0 5)。结果提示 :p53基因的突变以及由此导致的细胞异常增殖与喉癌的发生有密切关系 ,联合检测 p53蛋白表达及细胞增殖活性对判断喉AHE的发展趋势及LSCC的恶性程度有重要的参考价值。
The aim of our study was to analyze the correlation between tumor-cell kinectics and p53 protein expression in 11 cases of simple hyperplasia of epithelium(SHE),32 cases of atypical hyperplasia of epithelium(AHE) and 42 cases of laryngeal squamous cell carcinomas(LSCC) by means of immunohistochemical technique.The results showed that 0%,31 25%and 52 38% of SHE,AHE and LSCC were positive.The tumor-cell proliferative activity in p53 positive cases were significantly higher than those of p53 negative cases(P<0 05).Our data strongly suggest that overexpression of p53 protein is associated with rapid tumor-cell proliferation in these types of lesions and is of value in understanding the tendency of laryngeal premalignant lesions and the malignant potential of laryngeal carcinoma.

关键词(KeyWords): 喉肿瘤;蛋白质p53;细胞增殖
laryngeal neoplasms; protein p53;cell proliferation

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作者(Author): 周光耀,林代诚,梁传余,张贤良,文定厚,刘亚峰
Zhou Guangyao,et al Department of Otolaryngology,First Hospital,West China University of Medical Sciences

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