贵州医科大学学报

2020, v.45;No.237(06) 672-677

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贵阳市某社区中老年女性体质量指数和腰围与慢性肾脏病的相关性
Correlation between Body Mass Index,Waist Circumference of Middle-Aged and Elderly Women and Chronic Kidney Disease in Community of Guiyang City

文小芳;徐淑静;张巧;彭年春;胡颖;时立新;
WEN Xiaofang;XU Shujing;ZHANG Qiao;PENG Nianchun;HU Ying;SHI Lixin;Department of Endocrinology and Metabolism,the Affiliated Hospital of Guizhou Medical University;

摘要(Abstract):

目的:探讨贵阳市某社区中老年女性体质量指数(BMI)、腰围(WC)与慢性肾脏病(CKD)的相关性。方法:选取4 285例贵阳市某社区40~79岁中老年女性作为研究对象,检测清晨空腹的身高、体质量、WC及静息状态下的血压,计算BMI分析肥胖程度,根据WC记录腹型肥胖程度、根据血压判断高血压的发生情况;分别抽取研究对象空腹及葡萄糖耐量试验餐后2 h静脉血各5 m L,检测葡萄糖、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、总胆固醇(TC)、三酰甘油(TG)及血肌酐(SCr)水平,分析糖尿病、血脂异常、CKD的发生情况并计算肾小球滤过率(e GFR);采用Logistic回归分析中老年女性CKD发生的危险因素。结果:中老年女性居民糖尿病、高血压、血脂异常及CKD的患病率分别为13. 7%、26. 5%及48. 4%、5. 7%;随着年龄的增加,中老年女性居民的BMI、WC水平及CKD的患病率均增加(P <0. 001); e GFR水平随着中老年女性居民肥胖程度和腹型肥胖程度的增加而下降(P <0. 05或P <0. 001),肥胖和超重组中老年女性居民CKD患病率高于体质量正常组(P <0. 05),中心性肥胖组中老年女性居民CKD患病率明显高于正常腰围组和中心性肥胖前期组(P <0. 001); Logistic回归结果显示BMI、年龄、血脂异常、糖尿病及高血压均是中老年女性居民发生CKD的危险因素(P <0. 05),且BMI每增加一个水平,CKD的患病风险增加18. 8%(OR=1. 188,95%CI为1. 002~1. 408)。结论:贵阳市某社区中老年女性超重、肥胖及腹型肥胖组CKD患病率均高于正常组,而且肥胖指标BMI可增加CKD的患病风险。
Objective: To investigate the correlation between body mass index( BMI),waist circumference( WC) and chronic kidney disease( CKD) in middle-aged and elderly women in a community of Guiyang. Methods: 4,285 middle-aged and elderly women aged from 40-79 years in a community of Guiyang were selected as subjects of study. Their fasting height,body mass,WC and resting blood pressure in the morning were measured and BMI was calculated to analyze the degree of obesity. Abdominal obesity was recorded according to WC and the occurrence of hypertension was judged according to blood pressure. 5 m L of venous blood was extracted from the subjects after 2 h of fasting and glucose tolerance test. Glucose,low-denisity lipoprotein cholesterol( LDL-C),high-density lipoprotein cholesterol( HDL-C),total cholesterol( TL),triglyceride( TG) and serum creatinine( SCr)levels were detected. The occurrence of diabetes,dyslipidemia and CKD were analyzed,and the glomerular filtration rate( eGFR) was calculated. Risk factors for CKD in middle-aged and elderly women were analyzed by logistic regression. Results: Among middle-aged and elderly female residents,the prevalence of diabetes,hypertension,dyslipidemia and CKD were 13. 7%,26. 5%,48. 4% and 5. 7% respectively; With the increase of age,the prevalence of BMI、WC level and CKD of middle-aged and elderly female residents increased( P < 0. 001); The eGFR level decreased with the increase of obesity and abdominal obesity in middle-aged and elderly female residents( P < 0. 05 or P < 0. 001); The CKD prevalence of middle-aged and elderly female residents in obese and overweight group was higher than that in normal body mass group( P < 0. 05); The CKD prevalence of middleaged and elderly female residents in the central obesity group was significantly higher than that in the normal waist circumference group and the central pre-obesity group( P < 0. 001); Logistic regression results showed that BMI,age,dyslipidemia,diabetes and hypertension were all risk factors for CKD in middle-aged and elderly female residents( P < 0. 05); And the risk of CKD increased by 18. 8%( OR= 1. 188,95% CI = 1. 002 ~ 1. 408) for each increase in BMI. Conclusion: The prevalence of CKD in overweight,obese and abdominal obesity of middle-aged and elderly women in a community in Guiyang is higher than that in the normal group,and obesity index BMI could increase the risk of CKD.

关键词(KeyWords): 人体质量指数;腰围;肾小球滤过率;危险因素;慢性肾脏病;中老年人;女性
body mass index(BMI);waist circumference(WC);glomerular filtration rate(eGRF);risk factors;chronic kidney disease(CKD);middle-aged and elderly people;female

Abstract:

Keywords:

基金项目(Foundation): 2016年贵州省临床重点专科培育项目(SZD-2016-01)

作者(Author): 文小芳;徐淑静;张巧;彭年春;胡颖;时立新;
WEN Xiaofang;XU Shujing;ZHANG Qiao;PENG Nianchun;HU Ying;SHI Lixin;Department of Endocrinology and Metabolism,the Affiliated Hospital of Guizhou Medical University;

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DOI: 10.19367/j.cnki.2096-8388.2020.06.010

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