贵州医科大学学报

1988, (02) 239-244

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血清TGA、MCA测定在甲状腺疾病诊断中的价值——附585例分析
CLINICAL SIGNIFICANCE OF SERUM TGA AND MCA DETERMINATION FOR THE DIAGNOSIS OF THYROPATHIES

张家秀;孔德明;杨礼福;
Zhang Jiaxiu,Department of internal madicine

摘要(Abstract):

本文报道用血凝法测定585例甲状腺疾病和40例正常成人的血清 TGA、MCA。结果表明,其阳性检出率 AIT 组最高,为97.8%,Graves 病与原发性甲减次之,分别为61.5%与60.4%。其他各组均较低,正常成人仅占5%。在 Graves 病与 AIT 组以及原发性甲减与 AIT 之间关系密切。该两种抗体测定具有敏感,快速,特异性强之优点,对 AIA 之诊断有决定性意义。
The serum TGA and MCA determination of 585 patients with thypathy and 40 normal adults were carried out by means of hemagglutination test.Our estimation results reveal that the positive find rate are the highest(97.8%) in AIT group,the next(61.5% and 60.4%)in graves and primary hypothy- roidism groups,but lower in the other groups,and only 5% in the normal adu- lts.There are statistical significantly difference between the AIT group and the other groups(P<0.01).The majority of titer and distribution of serum TGA and MCA are≥1:2560 in the AIT group,but<1:2560 in the Graves group. It was also noted that thereare close correlation between graves and AIT, primary hypothyroidism and AIT.In addition,this paper even went a step further to prove that the hemagglutination tese has advantages of sen- sibility,speed and obvious specificity for the serum TGA and MCA determination, and has decisive significance for the diagnosis of AIT.The seneibility of MCA is higher than of TGA,and the positive find rate may be elerated as both are estimated simultaneously.

关键词(KeyWords): 甲状腺球蛋白抗体;微粒体抗体;自身免疫性甲状腺炎;Graves 病;甲状腺;功能减退
Thyroglobulin antibody;Microsomal antibody;Autoimmune thyroiditis;Graves disease;Hypothyroidism

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作者(Author): 张家秀;孔德明;杨礼福;
Zhang Jiaxiu,Department of internal madicine

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DOI: 10.19367/j.cnki.1000-2707.1988.02.028

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