贵州医科大学学报

1985, (02) 92-94

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三种农药的姐妹染色单体互换(SCE)试验
Sister-Chromatid Exehange (SCE) Test of Three Pesticides

蒋宪瑤;朱延韦;张爱华;
Jiang xianyao

摘要(Abstract):

用小鼠骨髓细胞(活体法)和人淋巴细胞(离体法)测定了三种农药的SCE频率,以了解其遗传效应活性。结果草甘膦无论活体法或离体法均可诱发SCE频率增高,活体法剂量为86mg/kg时,SCE频率为对照组的两倍,表明草甘膦不经代谢活化即有遗传效应活性,经代谢活化后遗传效应增高。敌百虫一尿素液活体法剂量达179mg/kg时,SCE效应为阴性,而离体法可诱发SCE频率增高,表明经代谢后失活。杀虫单活体法可诱发SCE频率增高,但未超过对照组的两倍。
The Sister-chromatid exchange (SCE) of three pesticides was tested for study- ing its activation of genetic effects with bone marrow cells of mice (in vivo) and human Iympho-cytes (in vitro). Whether in vivo or in vitro, glyphosate could induce the increse in SCEs. At dose of 86mg/kg, the increse of SCE rate was two-fo1d over control. It showed that glyphoaste has genetic effects without metabolic activation and has the increase of genetic effects with me- tabolic activation. At Close up to 179mg/kg of trichlophonurea, no increase in the SCE rate was observed, but in vitro it might induce the increase in SCEs. It was inactivated with metabolism. In vivo, Shachng-dan was found to induce the increase in SCE rate, which however did not double that of SCEs.

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作者(Author): 蒋宪瑤;朱延韦;张爱华;
Jiang xianyao

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