贵州医科大学学报

1995, (02)

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61例肾脏病患者血清唾液酸含量的测定
Measurements of serum Sialic Acid in 61 Cases of Patients with Renal Disease

杨国辉,朱春玲,周志邦,车筑萍
Yang Guohui,et al(Department of Internal Medicine Affiliated Hospital, Guiyang Medical College)

摘要(Abstract):

测定了61例肾脏病患者血清唾液酸(SA)含量。结果发现:肾病综合征、慢性肾功能不全、肾炎综合征及慢性肾盂肾炎的SA均值均显著高于正常(P<0.001)。并发现肾病综合征SA与补体C_3呈显著性负相关(P<0.05),肾炎综合征SA与补体C3、CH50呈显著性负相关(P<0.05),慢性肾功能不全SA与24h尿蛋白定量呈显著性负相关(P<0.05).表明肾病综合征、肾炎综合征SA增高可能与严重的免疫功能紊乱有关,慢性肾功能不全SA增高可能与多种因素抑制蛋白滤出有关。
Serum Sialic Acid(SA)was measured in 61 patients with renal disease.The results showed that the concentration of serum SA was 433.97±66. 45 ng/L in the controls(30 cases),559.44±72.19 ng/L(P<0.001),558.93±141.48 ng/L(P<0.001),553.71±88.21 ng/L(P<0.001),562.10±105.77 ng/L(P<0.001) in the patients groups with nephrotic syndrome(9 cases),chronic renal failure(15 cases), nephritis syndrome(17 cases)and chronic pyelonephritis(20 cases ).Nephrotic syndrome of te serum SA had a negative correlation with serum C3(1 158.11±301.32mg/L,r=-0.5141,P< 0.05). Nephritis syndrome of the serum SA had a negative correlation with serum C3(756.06±437.58mg/L,r=-0.644 9,P<0.05) and CH50(74.94±29.52 kU/L,r=-0.447 5, P<0.05), chronic renal failure of the serum SA had a negative correlation with 24 h urine protein(2 170.69±1186.85 mg/24 h,r=-0.513 5,P<0.05). The date indicated that the abnormal level of the plasma C3,CH50 plays a role in the nephrotic syndrome and nephritis syndrome of the serum SA markedly higher, the abnormal level of 24 h urine protein plays a role in the chronic renal failure of the serum SA markedly higher.

关键词(KeyWords): 唾液酸类,肾疾病
sialic acids;kidney diseases

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作者(Author): 杨国辉,朱春玲,周志邦,车筑萍
Yang Guohui,et al(Department of Internal Medicine Affiliated Hospital, Guiyang Medical College)

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